ROLE OF HETEROTRIMERIC GTP-BINDING PROTEINS IN VESICULAR PROTEIN-TRANSPORT - INDICATIONS FOR BOTH CLASSICAL AND ALTERNATIVE G-PROTEIN CYCLES

被引：76

作者：

HELMS, JB

机构：

来源：

FEBS LETTERS | 1995年 / 369卷 / 01期

关键词：

HETEROTRIMERIC GTP BINDING PROTEIN; VESICULAR TRAFFICKING; SIGNAL TRANSDUCTION; GOLGI APPARATUS; SECRETORY PATHWAY; ENDOCYTIC PATHWAY;

D O I：

10.1016/0014-5793(95)00620-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heterotrimeric G proteins are involved in hormonal signal transduction across the plasma membrane. Recent evidence suggests that they have a role in vesicular protein transport as well, Biochemical probes that interfere with the classical G protein cycle have been applied to the field of intracellular membrane transport to study their mechanism of action. Evidence has been obtained that intracellular G proteins act both through classical and alternative G protein cycles.

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页码：84 / 88

页数：5

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共 79 条

[11] ARF PROTEINS - THE MEMBRANE TRAFFIC POLICE [J].

BOMAN, AL ;

KAHN, RA .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (04) :147-150

[12]

BOMSEL M, 1993, J BIOL CHEM, V268, P25824

[13] ROLE OF HETEROTRIMERIC-G PROTEINS IN MEMBRANE TRAFFIC [J].

BOMSEL, M ;

MOSTOV, K .

MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (12) :1317-1328

[14] THE GTPASE SUPERFAMILY - A CONSERVED SWITCH FOR DIVERSE CELL FUNCTIONS [J].

BOURNE, HR ;

SANDERS, DA ;

MCCORMICK, F .

NATURE, 1990, 348 (6297) :125-132

[15] MULTIPLE GTP-BINDING PROTEINS PARTICIPATE IN CLATHRIN-COATED VESICLE-MEDIATED ENDOCYTOSIS [J].

CARTER, LL ;

REDELMEIER, TE ;

WOOLLENWEBER, LA ;

SCHMID, SL .

JOURNAL OF CELL BIOLOGY, 1993, 120 (01) :37-45

[16] ALUMINOFLUORIDE AND BERYLLOFLUORIDE COMPLEXES - NEW PHOSPHATE ANALOGS IN ENZYMOLOGY [J].

CHABRE, M .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (01) :6-10

[17] NEW ROLES FOR G-PROTEIN BETA-GAMMA-DIMERS IN TRANSMEMBRANE SIGNALING [J].

CLAPHAM, DE ;

NEER, EJ .

NATURE, 1993, 365 (6445) :403-406

[18] DEMONSTRATION OF THE PRESENCE OF G-PROTEINS IN HEPATIC-MICROSOMAL FRACTION [J].

CODINA, J ;

KIMURA, S ;

KRAUSFRIEDMANN, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 150 (02) :848-852

[19] STRUCTURES OF ACTIVE CONFORMATIONS OF G(I-ALPHA-1) AND THE MECHANISM OF GTP HYDROLYSIS [J].

COLEMAN, DE ;

BERGHUIS, AM ;

LEE, E ;

LINDER, ME ;

GILMAN, AG ;

SPRANG, SR .

SCIENCE, 1994, 265 (5177) :1405-1412

[20] EVIDENCE OF A ROLE FOR HETEROTRIMERIC GTP-BINDING PROTEINS IN ENDOSOME FUSION [J].

COLOMBO, MI ;

MAYORGA, LS ;

CASEY, PJ ;

STAHL, PD .

SCIENCE, 1992, 255 (5052) :1695-1697

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