Bioactive guanidine alkaloids from Pterogyne nitens

被引：28

作者：

Bolzani, VDS

Gunatilaka, AAL

Kingston, DGI

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

[2] UNIV ESTADUAL PAULISTA,INST QUIM,BR-14800 ARARAQUARA,SP,BRAZIL

来源：

JOURNAL OF NATURAL PRODUCTS | 1995年 / 58卷 / 11期

关键词：

D O I：

10.1021/np50125a006

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Bioactivity-guided fractionation of a methanolic CHCl3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine (2) and three new guanidine alkaloids, nitensidines A (3), B (4), and C (5), all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC12 = 9.3 - 20.0 mu g/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B-1 cells (IC50 = 8.5 - 13.0 mu g/ml).

引用

页码：1683 / 1688

页数：6

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