SOLID-PHASE SYNTHESIS OF A NUCLEOPEPTIDE FROM THE LINKING SITE OF ADENOVIRUS-2 NUCLEOPROTEIN, -SER(P5'CATCAT)-GLY-ASP- - CONVERGENT VERSUS STEPWISE STRATEGY

The synthesis of a nucleopeptide with the sequence -Ser(p(5')CATCAT)-Gly-Asp- has been undertaken by either convergent or stepwise solid-phase strategies, both of which use base-labile permanent protecting groups, The coupling of phosphitylated protected peptides onto oligonucleotide-resins did not afford the desired nucleopeptide, which was nevertheless obtained after oligonucleotide elongation at the hydroxyl group of the resin-bound peptide and deprotection under mild basic conditions, A preliminary study on the stability of different nucleopeptides to bases is also reported.