PHASE-TRANSITION FROM A GEL TO A FLUID PHASE OF CUBIC SYMMETRY IN DIMYRISTOYLPHOSPHATIDYLCHOLINE MYRISTIC ACID (1-2, MOL MOL) BILAYERS

被引:24
作者
HEIMBURG, T
RYBA, NJP
WURZ, U
MARSH, D
机构
[1] MAX PLANCK INST BIOPHYS CHEM,SPEKT ABT,W-3400 GOTTINGEN,GERMANY
[2] MAX PLANCK INST BIOPHYS CHEM,KINET PHASENBILDUNG ABT,W-3400 GOTTINGEN,GERMANY
关键词
Cubic phase; Fatty acid; Hexagonal H[!sub]II[!/sub] phase; NMR; !sup]2[!/sup]H-; Phospholipid bilayer; X-ray diffraction;
D O I
10.1016/0005-2736(90)90192-Q
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aqueous dispersions (pH 4.0) of a 2:1 (mol/mol) mixture of myristic acid with dimyristoylphosphatidylcholine undergo a sharp transition at 45-47°C from a lamellar gel phase to a fluid phase which is optically isotropic. This fluid phase gives rise to 31P-NMR spectra, and 2H-NMR spectra of the chain-deuterated components, which are also isotropic. X-ray diffraction studies of the fluid phase at 49°C, reveal reflections with spacings in the ratio √2: (√3): √4: √6: √8, accompanied by a strong diffuse scatter. These reflections index on a cubic lattice of primitive space group Pn3 or Pn3m, or possibly the body-centered group Im3m, with a lattice constant of 21.2 nm. The dimensions of the phase are consistent with a structure composed of two systems of tetrahedrally (octahedrally) oriented inverted lipid cylinders, found for other cubic lipid phases with Pn3m (Im3m) symmetry. At higher temperatures the cubic phase gradually converts, with increasing temperature, to a coexisting inverted hexagonal phase. © 1990.
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页码:77 / 81
页数:5
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