N-O DIHETEROCYCLIC NUCLEOSIDES - SYNTHESIS OF 2'-N-METHYL-3'-HYDROXYMETHYL-1',2'-ISOXAZOLIDINYLTHYMID

被引：25

作者：

XIANG, YJ

CHEN, J

SCHINAZI, RF

ZHAO, K

机构：

[1] NYU,DEPT CHEM,NEW YORK,NY 10003

[2] VET AFFAIRS MED CTR,GEORGIA RES CTR AIDS & HIV INFECT,DECATUR,GA 30033

[3] EMORY UNIV,SCH MED,DEPT PEDIAT,BIOCHEM PHARMACOL LAB,ATLANTA,GA 30322

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 40期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0040-4039(95)01499-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isoxazolidine thymidine derivatives were synthesized by the condensation of silylated thymine with isoxazolidinyl acetate prepared by the Michael addition of an alpha,beta-unsaturated ester with N-methylhydroxyamine followed by DIBAL reduction and acetate production.

引用

收藏

页码：7193 / 7196

页数：4

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