BIOCATALYTIC RESOLUTION OF DL-PROPRANOLOL - A SUCCESSFUL EXAMPLE OF COMPUTER-AIDED SUBSTRATE DESIGN

被引：11

作者：

CHEN, CS

GOU, DM

SHIEH, WR

LIU, YC

机构：

[1] Department of Pharmacognosy, Environmental Health Sciences College of Pharmacy, University of Rhode Island, Kingston

来源：

TETRAHEDRON | 1993年 / 49卷 / 16期

关键词：

D O I：

10.1016/S0040-4020(01)90157-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An approach entailing computer-aided substrate design was taken to develop biocatalytic resolution of racemic propranolol. This strategy provided useful insight into potential steric factors within the substrate, which might be crucial to the catalytic turnover and enantiomeric selection.

引用

页码：3281 / 3290

页数：10

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