ASCORBIC-ACID SUPPLEMENTATION PREVENTS HYPERLIPIDEMIA AND IMPROVES MYOCARDIAL PERFORMANCE IN STREPTOZOTOCIN-DIABETIC RATS

被引：22

作者：

DAL, S ^{[1
]}

MCNEILL, JH ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA, FAC PHARMACEUT SCI, DIV PHARMACOL & TOXICOL, VANCOUVER, BC V6T 1Z3, CANADA

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1995年 / 27卷 / 01期

关键词：

ASCORBIC ACID; DIABETES; CARDIAC DYSFUNCTION; HYPERLIPIDEMIA; RAT;

D O I：

10.1016/0168-8227(94)01013-P

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present study investigated the effects of ascorbic acid (AA) supplementation on the cardiac performance and the plasma levels of glucose, insulin, triglycerides, cholesterol and free fatty acid in diabetic and non-diabetic rats. Diabetes was induced by intravenous injection of streptozotocin (STZ) 55 mg/kg. AA was given in drinking water in concentrations of 1 g/l or 2 g/l for 8 weeks after STZ injection. Myocardial performance was determined using the isolated perfused working heart preparations. Following AA supplementation, there were no significant changes in any of the parameters measured in non-diabetic rats; however, the occurrence of polydipsia, hyperphagia, hyperlipidemia and myocardial dysfunction in STZ-diabetic rats was significantly alleviated in a dose-dependent manner. Nevertheless, the decreased body weight gain, hypoinsulinemia and hyperglycemia in diabetic animals were not affected. The data show that AA supplementation in STZ-diabetic rats improves both hyperlipidemia and cardiac function. However, the mechanisms of these effects and the correlation between these improvements are not dear.

引用

页码：11 / 18

页数：8

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