A HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF 4-ALKYL THREO GLUTAMIC ACIDS

被引：14

作者：

GU, ZQ

HESSON, DP

机构：

[1] Department of Medicinal Chemistry, Symphony Pharmaceuticals Inc., Malvern, PA 19355

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 09期

关键词：

D O I：

10.1016/0957-4166(95)00274-S

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Treatment of N-p-nitrobenzoyl L- or D-glutamic acid diester with lithium bis(trimethylsilyl)amide generates a chelated gamma-enolate which reacts with alkyl halides to give (2S,4S)- or (2R,4R)-4-alkylated glutamic acid derivatives with very high diastereoselectivity.

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页码：2101 / 2104

页数：4

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