PROTECTIVE ROLE OF VITAMIN-E IN BIOLOGICAL-SYSTEMS

被引:371
作者
PACKER, L
机构
[1] Dept. of Molecular and Cell Biology, University of California, Berkeley, CA
[2] Dept. of Molecular and Cell Biology, University of California, Berkeley
关键词
VITAMIN-E; ANTIOXIDANTS; FREE RADICALS; CANCER; AGING; POLLUTION; EXERCISE;
D O I
10.1093/ajcn/53.4.1050S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Vitamin E is well accepted as nature's most effective lipid-soluble, chain-breaking antioxidant, protecting cell membranes from peroxidative damage. Free-radical-mediated pathology has been implicated in the development over time of degenerative diseases and conditions. This paper reviews the current research on the protective role and requirements for vitamin E and the other antioxidants in preventing or minimizing free-radical damage associated with specific diseases and lifestyle patterns and processes, including cancer, aging, circulatory conditions, arthritis, cataract, pollution, and strenuous exercise. While awaiting results of further human studies, research evidence suggests that an adequate intake of vitamin E and the other antioxidants can provide protection from the increasingly high free-radical concentrations caused by air pollutants and current lifestyle patterns.
引用
收藏
页码:S1050 / S1055
页数:6
相关论文
共 67 条
[51]  
STEINER M, 1983, THROMB HAEMOSTASIS, V49, P73
[52]  
SZCZEKLIK A, 1985, THROMB HAEMOSTASIS, V54, P425
[53]  
Tannenbaum S R, 1980, Ann N Y Acad Sci, V355, P267, DOI 10.1111/j.1749-6632.1980.tb21345.x
[54]   ANTI-OXIDANT SUPPLEMENTATION DECREASES TBA REACTANTS IN SERUM OF ELDERLY [J].
TOLONEN, M ;
SARNA, S ;
HALME, M ;
TUOMINEN, SEJ ;
WESTERMARCK, T ;
NORDBERG, UR ;
KEINONEN, M ;
SCHRIJVER, J .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1988, 17 :221-228
[55]   VITAMIN-E AND SELENIUM SUPPLEMENTATION IN GERIATRIC-PATIENTS - A DOUBLE-BLIND PRELIMINARY CLINICAL-TRIAL [J].
TOLONEN, M ;
HALME, M ;
SARNA, S .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1985, 7 (03) :161-168
[56]  
TOP AG, 1986, PORIM B, V12, P32
[57]  
TOPO AG, 1983, PALM OIL PRODUCT TEC, P145
[58]  
TREVITHICK JR, 1981, CAN J OPHTHALMOL, V16, P32
[59]   PREVENTION BY VITAMIN-E OF EXPERIMENTAL ORAL CARCINOGENESIS [J].
TRICKLER, D ;
SHKLAR, G .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1987, 78 (01) :165-169
[60]   INCREASED LIPID-PEROXIDATION AFTER LIPID INFUSION AS MEASURED BY BREATH PENTANE OUTPUT [J].
VANGOSSUM, A ;
SHARIFF, R ;
LEMOYNE, M ;
KURIAN, R ;
JEEJEEBHOY, K .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1988, 48 (06) :1394-1399