THE SPIN TRAP, ALPHA-PHENYL N-TERT-BUTYLNITRONE, INHIBITS THE OXIDATIVE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN

被引：42

作者：

KALYANARAMAN, B ^{[1
]}

JOSEPH, J ^{[1
]}

PARTHASARATHY, S ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT MED,LA JOLLA,CA 92930

来源：

FEBS LETTERS | 1991年 / 280卷 / 01期

关键词：

ATHEROSCLEROSIS; LIPID-DERIVED RADICAL; ELECTRON SPIN RESONANCE (ESR); LIPID PEROXIDATION;

D O I：

10.1016/0014-5793(91)80194-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipophilic spin trap, N-tert-butylnitrone (PBN) inhibits the formation of the oxidatively-modified low density lipoprotein (LDL) by endothelial cells and by cupric ions. The LDL incubated in the presence of PBN with cells or cupric ions was less readily degraded by macrophages than the LDL incubated in the absence of PBN. A lipid-derived radical formed during oxidation of LDL was detected by spin trapping with PBN. It is likely that PBN inhibits the oxidative and biological modification of LDL by scavenging the LDL-lipid-derived radical.

引用

页码：17 / 20

页数：4

共 24 条

[11] ENHANCED MACROPHAGE DEGRADATION OF LOW-DENSITY LIPOPROTEIN PREVIOUSLY INCUBATED WITH CULTURED ENDOTHELIAL-CELLS - RECOGNITION BY RECEPTORS FOR ACETYLATED LOW-DENSITY LIPOPROTEINS [J].