HUMANIZED ANTIBODIES

被引：56

作者：

WINTER, G

HARRIS, WJ

机构：

[1] MRC,CTR PROT ENGN,CAMBRIDGE CB2 2QH,ENGLAND

[2] UNIV ABERDEEN MARISCHAL COLL,DEPT MOLEC & CELL BIOL,ABERDEEN AB9 1AS,SCOTLAND

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1993年 / 14卷 / 05期

关键词：

D O I：

10.1016/0165-6147(93)90197-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering, reviewed here by Greg Winter and William Harris, is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies. Humanized antibodies have improved pharmacokinetics, reduced immunogenicity and have been used to clinical advantage.

引用

收藏

页码：139 / 143

页数：5

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