INDUCTION OF CYTOCHROME-P450 ISOFORMS BY CARCINOGENIC AROMATIC-AMINES AND CARCINOGENIC SUSCEPTIBILITY OF RODENT ANIMALS

被引:9
作者
HASHIMOTO, Y [1 ]
DEGAWA, M [1 ]
机构
[1] TOHOKU UNIV,FAC PHARMACEUT SCI,DEPT HYG CHEM,AOBA KU,SENDAI,MIYAGI 98077,JAPAN
来源
PHARMACOGENETICS | 1995年 / 5卷
关键词
D O I
10.1097/00008571-199512001-00006
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Hepatocarcinogenic aromatic amines such as 4-aminoazobenzene derivatives and heterocyclic aromatic amines of cooked food origin were found to be liver-selective cytochrome P450IAZ (CYP1A2) inducers. Each aromatic amine showed different species-specificity among rodent experimental animals in terms of the extent of P450 induction. Carcinogenic susceptibility of an animal to the amine was well correlated with the activity and/or inducibility of CYP1A2 in the animals in the early initiation phase of the carcinogenesis. In hyperplastic nodules of rat liver, expression and induction of CYP1A2 as suppressed, especially in the placental form of glutathione S-transferase-positive foci, Despite the decrease of P450s including CYP1A2 in the rat liver bearing hyperplastic nodules, DNA adducts formed by a carcinogenic aromatic amine increased, as compared to the controls, suggesting that the activity of DNA repair enzyme(s) for the amine-derived DNA adducts might decrease in the hyperplastic nodules of rat liver. Treatment of rats with lead nitrate revealed a pattern of P450 expression in the liver similar to that observed with rats bearing hyperplastic nodules. These findings may provide valuable information on the roles of P450s in carcinogenic susceptibility of animals to aromatic amines and in the carcinogenic process.
引用
收藏
页码:S80 / S83
页数:4
相关论文
共 22 条
[2]   EXPRESSION AND INDUCTION OF CYTOCHROME P450 ISOZYMES IN HYPERPLASTIC NODULES OF RAT-LIVER [J].
DEGAWA, M ;
MIURA, S ;
HASHIMOTO, Y .
CARCINOGENESIS, 1991, 12 (11) :2151-2156
[3]   HEPATIC CYTOCHROME-P-450 ISOZYME(S) INDUCED BY DIETARY CARCINOGENIC AROMATIC-AMINES PREFERENTIALLY IN FEMALE MICE OF DBA/2 AND OTHER STRAINS [J].
DEGAWA, M ;
YAMAYA, C ;
HASHIMOTO, Y .
CARCINOGENESIS, 1988, 9 (04) :567-571
[4]  
DEGAWA M, 1985, CANCER RES, V45, P96
[5]   INDUCTION OF A HIGH-SPIN FORM OF MICROSOMAL CYTOCHROME-P-448 IN RAT-LIVER BY 4-AMINOAZOBENZENE DERIVATIVES [J].
DEGAWA, M ;
KOJIMA, M ;
SATO, Y ;
HASHIMOTO, Y .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (20) :3565-3570
[6]   IONIC LEAD, A UNIQUE METAL-ION AS AN INHIBITOR FOR CYTOCHROME P450IA2 (CYP1A2) EXPRESSION IN THE RAT-LIVER [J].
DEGAWA, M ;
ARAI, H ;
KUBOTA, M ;
HASHIMOTO, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 200 (02) :1086-1092
[7]   HEPATOCARCINOGENIC HETEROCYCLIC AROMATIC-AMINES THAT INDUCE CYTOCHROME-P-448 ISOZYMES, MAINLY CYTOCHROME-P-448H (P-450IA2), RESPONSIBLE FOR MUTAGENIC ACTIVATION OF THE CARCINOGENS IN RAT-LIVER [J].
DEGAWA, M ;
TANIMURA, S ;
AGATSUMA, T ;
HASHIMOTO, Y .
CARCINOGENESIS, 1989, 10 (06) :1119-1122
[8]   SPECIES, SEX AND ORGAN DIFFERENCES IN INDUCTION OF A CYTOCHROME-P-450 ISOZYME RESPONSIBLE FOR CARCINOGEN ACTIVATION - EFFECTS OF DIETARY HEPATOCARCINOGENIC TRYPTOPHAN PYROLYSATE COMPONENTS IN MICE AND RATS [J].
DEGAWA, M ;
HISHINUMA, T ;
YOSHIDA, H ;
HASHIMOTO, Y .
CARCINOGENESIS, 1987, 8 (12) :1913-1918
[9]   SPECIES-DIFFERENCE AMONG EXPERIMENTAL RODENTS IN THE ACTIVITY AND INDUCTION OF CYTOCHROME-P-450 ISOZYMES FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AROMATIC-AMINES [J].
DEGAWA, M ;
AGATSUMA, T ;
HASHIMOTO, Y .
JAPANESE JOURNAL OF CANCER RESEARCH, 1990, 81 (12) :1253-1258
[10]   SPECIES-DIFFERENCE AMONG EXPERIMENTAL RODENTS IN INDUCTION OF P450IA FAMILY ENZYMES BY 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE [J].
DEGAWA, M ;
KOBAYASHI, K ;
MIURA, S ;
ARAI, H ;
ESUMI, H ;
SUGIMURA, T ;
HASHIMOTO, Y .
JAPANESE JOURNAL OF CANCER RESEARCH, 1992, 83 (10) :1047-1051