ADENOVIRAL VECTORS FOR GENE-TRANSFER

被引：98

作者：

TRAPNELL, BC

机构：

[1] Department of Virology, Genetic Therapy, Inc., Gaithersburg, MD

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1993年 / 12卷 / 03期

关键词：

IN-VIVO GENE THERAPY; GENETIC DISORDERS; ADENOVIRUS-BASED VACCINES;

D O I：

10.1016/0169-409X(93)90059-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper reviews the current information regarding the use of human adenoviruses as vehicles for transfer of genetic material into mammalian cells. The clinical aspects and genetic program or molecular biology of natural, wild-type adenovirus infection will be discussed in order to provide a background for understanding the pharmacology and toxicology of adenoviral gene transfer vectors. The use of adenovirus itself and adenovirus-based vectors as vaccines is reviewed as well as the use of adenoviral vectors for gene transfer. Adenoviral vectors provide an important potential in vivo delivery vehicle for immunization strategies as well as genetic therapy for correction of genetic and acquired diseases.

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页码：185 / 199

页数：15

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