d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties

被引：245

作者：

Tasinato, A ^{[1
]}

Boscoboinik, D ^{[1
]}

Bartoli, GM ^{[1
]}

Maroni, P ^{[1
]}

Azzi, A ^{[1
]}

机构：

[1] UNIV BERN, INST BIOCHEM & MOLEK BIOL, CH-3012 BERN, SWITZERLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 26期

关键词：

D O I：

10.1073/pnas.92.26.12190

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

d-alpha-Tocopherol, but not d-beta-tocopherol, negatively regulates proliferation of vascular smooth muscle cells at physiological concentrations, d-alpha-Tocopherol inhibits protein kinase C (PKC) activity, whereas d-beta-tocopherol is ineffective, Furthermore d-beta-tocopherol prevents the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol, The negative regulation by d-alpha-tocopherol of PI;C activity appears to be the cause and not the effect of smooth muscle cell growth inhibition, d-alpha-Tocopherol does not act by binding to PKC directly but presumably by preventing PKC activation, It is concluded that, in vascular smooth muscle cells, d-alpha-tocopherol acts specifically through a nonantioxidant mechanism and exerts a negative control on a signal transduction path,cay regulating cell proliferation.

引用

页码：12190 / 12194

页数：5

共 56 条

[31] KUZUYA M, 1991, ARTERY, V18, P115
[32] LIEBLER DC, 1986, J BIOL CHEM, V261, P2114
[33] FATTY-ACID METABOLISM AND CELL-PROLIFERATION .7. ANTIOXIDANT EFFECTS OF TOCOPHEROLS AND THEIR QUINONES
LINDSEY, JA
ZHANG, H
KASEKI, H
MORISAKI, N
SATO, T
CORNWELL, DG
[J]. LIPIDS, 1985, 20 (03) : 151 - 157
[34] REGULATION OF THE TRANSCRIPTION FACTORS NF-KAPPA-B AND AP-1 BY REDOX CHANGES
MEYER, M
PAHL, HL
BAEUERLE, PA
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1994, 91 (2-3) : 91 - 100
[35] FATTY-ACID SPECIFICITY IN THE INHIBITION OF CELL-PROLIFERATION AND ITS RELATIONSHIP TO LIPID-PEROXIDATION AND PROSTAGLANDIN BIOSYNTHESIS
MORISAKI, N
SPRECHER, H
MILO, GE
CORNWELL, DG
[J]. LIPIDS, 1982, 17 (12) : 893 - 899
[36] FATTY-ACID METABOLISM AND CELL-PROLIFERATION .5. EVALUATION OF PATHWAYS FOR THE GENERATION OF LIPID PEROXIDES
MORISAKI, N
LINDSEY, JA
STITTS, JM
ZHANG, HF
CORNWELL, DG
[J]. LIPIDS, 1984, 19 (06) : 381 - 394
[37] MORISAKI N, 1992, J NUTR SCI VITAMINOL, P196
[38] OLIVIER AR, 1994, J BIOL CHEM, V269, P2758
[39] D-ALPHA-TOCOPHEROL INHIBITS LOW-DENSITY-LIPOPROTEIN INDUCED PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY IN VASCULAR SMOOTH-MUSCLE CELLS
OZER, NK
PALOZZA, P
BOSCOBOINIK, D
AZZI, A
[J]. FEBS LETTERS, 1993, 322 (03) : 307 - 310
[40] STUDIES ON THE PHOSPHORYLATION OF PROTEIN KINASE-C-ALPHA
PEARS, C
STABEL, S
CAZAUBON, S
PARKER, PJ
[J]. BIOCHEMICAL JOURNAL, 1992, 283 : 515 - 518

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