PENICILLIN DERIVED C2-SYMMETRICAL DIMERS AS NOVEL INHIBITORS OF HIV-1 PROTEINASE

被引:44
作者
HUMBER, DC
CAMMACK, N
COATES, JAV
COBLEY, KN
ORR, DC
STORER, R
WEINGARTEN, GG
WEIR, MP
机构
[1] GLAXO GRP RES LTD,DEPT VIROL,GREENFORD UB6 0HE,MIDDX,ENGLAND
[2] GLAXO GRP RES LTD,DEPT GENET,GREENFORD UB6 0HE,MIDDX,ENGLAND
关键词
D O I
10.1021/jm00094a024
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:3080 / 3081
页数:2
相关论文
共 13 条
[1]   CARBOVIR - THE (-) ENANTIOMER IS A POTENT AND SELECTIVE ANTIVIRAL AGENT AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS INVITRO [J].
COATES, JAV ;
INGGALL, HJ ;
PEARSON, BA ;
PENN, CR ;
STORER, R ;
WILLIAMSON, C ;
CAMERON, JM .
ANTIVIRAL RESEARCH, 1991, 15 (02) :161-168
[2]   DESIGN, ACTIVITY, AND 2.8 A CRYSTAL-STRUCTURE OF A C2 SYMMETRICAL INHIBITOR COMPLEXED TO HIV-1 PROTEASE [J].
ERICKSON, J ;
NEIDHART, DJ ;
VANDRIE, J ;
KEMPF, DJ ;
WANG, XC ;
NORBECK, DW ;
PLATTNER, JJ ;
RITTENHOUSE, JW ;
TURON, M ;
WIDEBURG, N ;
KOHLBRENNER, WE ;
SIMMER, R ;
HELFRICH, R ;
PAUL, DA ;
KNIGGE, M .
SCIENCE, 1990, 249 (4968) :527-533
[3]   HIV PROTEASE - A NOVEL CHEMOTHERAPEUTIC TARGET FOR AIDS [J].
HUFF, JR .
JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) :2305-2314
[4]   VIRAL PROTEINASES - WEAKNESS IN STRENGTH [J].
KAY, J ;
DUNN, BM .
BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1048 (01) :1-18
[5]   STRUCTURE-BASED, C2 SYMMETRICAL INHIBITORS OF HIV PROTEASE [J].
KEMPF, DJ ;
NORBECK, DW ;
CODACOVI, LM ;
WANG, XC ;
KOHLBRENNER, WE ;
WIDEBURG, NE ;
PAUL, DA ;
KNIGGE, MF ;
VASAVANONDA, S ;
CRAIGKENNARD, A ;
SALDIVAR, A ;
ROSENBROOK, W ;
CLEMENT, JJ ;
PLATTNER, JJ ;
ERICKSON, J .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (10) :2687-2689
[6]   ACTIVE HUMAN IMMUNODEFICIENCY VIRUS PROTEASE IS REQUIRED FOR VIRAL INFECTIVITY [J].
KOHL, NE ;
EMINI, EA ;
SCHLEIF, WA ;
DAVIS, LJ ;
HEIMBACH, JC ;
DIXON, RAF ;
SCOLNICK, EM ;
SIGAL, IS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) :4686-4690
[7]   EXPRESSION OF AN AUTOPROCESSING CAT-HIV-1 PROTEINASE FUSION PROTEIN - PURIFICATION TO HOMOGENEITY OF THE RELEASED 99-RESIDUE PROTEINASE [J].
MONTGOMERY, DS ;
SINGH, OMP ;
GRAY, NM ;
DYKES, CW ;
WEIR, MP ;
HOBDEN, AN .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (03) :784-794
[8]   3-DIMENSIONAL STRUCTURE OF ASPARTYL PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS HIV-1 [J].
NAVIA, MA ;
FITZGERALD, PMD ;
MCKEEVER, BM ;
LEU, CT ;
HEIMBACH, JC ;
HERBER, WK ;
SIGAL, IS ;
DARKE, PL ;
SPRINGER, JP .
NATURE, 1989, 337 (6208) :615-620
[9]   RAPID AND AUTOMATED TETRAZOLIUM-BASED COLORIMETRIC ASSAY FOR THE DETECTION OF ANTI-HIV COMPOUNDS [J].
PAUWELS, R ;
BALZARINI, J ;
BABA, M ;
SNOECK, R ;
SCHOLS, D ;
HERDEWIJN, P ;
DESMYTER, J ;
DECLERCQ, E .
JOURNAL OF VIROLOGICAL METHODS, 1988, 20 (04) :309-321
[10]   A NEW CONVENIENT METHOD FOR ESTERIFICATION USING THE PH3P/CCL4 SYSTEM [J].
RAMAIAH, M .
JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (24) :4991-4993