SINGLE-FLASK POLYFUNCTIONALIZATION OF THE IMIDAZOLE RING - A STREAMLINED ROUTE TO THE ANTITUMOR AGENT CARMETHIZOLE

被引：45

作者：

LIPSHUTZ, BH

HAGEN, W

机构：

[1] Department of Chemistry University of California, CA 93106 U.S.A. [, Santa Barbara

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(00)61074-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three sequential treatments of an N-protected tribromoimidazole with n-BuLi / electrophile in a 1-pot process leads to N-protected 2,4,5-trisubstituted imidazoles. The method can be applied to the preparation of the immediate precursor of carmethizole.

引用

页码：5865 / 5868

页数：4

共 18 条

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