SYNTHESIS AND PROPERTIES OF MECHANISM-BASED INHIBITORS AND PROBES FOR INOSITOL MONOPHOSPHATASE DERIVED FROM 6-O-(2'-HYDROXYETHYL)-(1R,2R,4R6R)-CYCLOHEXANE-1,2,4,6-TETRAOL

被引：19

作者：

SCHULZ, J

WILKIE, J

LIGHTFOOT, P

RUTHERFORD, T

GANI, D

机构：

[1] UNIV ST ANDREWS,SCH CHEM,ST ANDREWS KY16 9ST,FIFE,SCOTLAND

[2] UNIV ST ANDREWS,CTR BIOMOLEC SCI,ST ANDREWS KY16 9ST,FIFE,SCOTLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 22期

关键词：

D O I：

10.1039/C39950002353

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 1-phosphate, 2'-phbsphate and 1,2'-cydlid phosphate of 6-O-(2-hydroxyethyl)-cyclohexane-1,2,4,6-tetraol are synthesised and found to be good inhibitors of inositol monophosphatase; the stereochemistry of the most potent inhibitor, the (1R,2R,4R,6R)-1-phosphate, provides useful mechanistic insight into the action of this enzyme, the putative target for lithium therapy.

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页码：2353 / 2356

页数：4

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