BIDIRECTIONAL REGULATION OF NA+,K+-ATPASE ACTIVITY BY DOPAMINE AND AN ALPHA-ADRENERGIC AGONIST

被引:82
作者
IBARRA, F
APERIA, A
SVENSSON, LB
EKLOF, AC
GREENGARD, P
机构
[1] KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PEDIAT, S-11281 STOCKHOLM, SWEDEN
[2] ROCKEFELLER UNIV, MOLEC & CELLULAR NEUROSCI LAB, NEW YORK, NY 10021 USA
关键词
ALPHA-ADRENERGIC RECEPTORS; NATRIURESIS; PROXIMAL TUBULES; PHOSPHATASE INHIBITORS;
D O I
10.1073/pnas.90.1.21
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Catecholamines have pronounced effects on the renal handling of sodium and water, dopamine-promoting sodium and water excretion, and norepinephrine-promoting sodium and water retention. In the present study, using isolated permeabilized renal tubule cells and intact rats, we have shown that these effects can be attributed to opposing actions of these transmitters on renal tubular Na+,K+-ATPase activity. The ability of each of these catecholamines to regulate Na+,K+-ATPase activity is affected by the concentration of Na+ as well as by the absence or presence of the opposing catecholamine.
引用
收藏
页码:21 / 24
页数:4
相关论文
共 19 条
[1]   PHOSPHORYLATED MR 32,000 DOPAMINE- AND CAMP-REGULATED PHOSPHOPROTEIN INHIBITS NA+,K+-ATPASE ACTIVITY IN RENAL TUBULE CELLS [J].
APERIA, A ;
FRYCKSTEDT, J ;
SVENSSON, L ;
HEMMINGS, HC ;
NAIRN, AC ;
GREENGARD, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2798-2801
[2]   CALCINEURIN MEDIATES ALPHA-ADRENERGIC STIMULATION OF NA+,K+-ATPASE ACTIVITY IN RENAL TUBULE CELLS [J].
APERIA, A ;
IBARRA, F ;
SVENSSON, LB ;
KLEE, C ;
GREENGARD, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) :7394-7397
[3]   DOPAMINE CAUSES INHIBITION OF NA+-K+-ATPASE ACTIVITY IN RAT PROXIMAL CONVOLUTED TUBULE SEGMENTS [J].
APERIA, A ;
BERTORELLO, A ;
SERI, I .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (01) :F39-F45
[4]  
APERIA A, 1991, CONTEMP ISS NEPHROL, P315
[5]   DOPAMINE DECREASES FLUID REABSORPTION IN STRAIGHT PORTIONS OF RABBIT PROXIMAL TUBULE [J].
BELLOREUSS, E ;
HIGASHI, Y ;
KANEDA, Y .
AMERICAN JOURNAL OF PHYSIOLOGY, 1982, 242 (06) :F634-F640
[6]   INHIBITION OF PROXIMAL TUBULE NA+-K+-ATPASE ACTIVITY REQUIRES SIMULTANEOUS ACTIVATION OF DA1 AND DA2 RECEPTORS [J].
BERTORELLO, A ;
APERIA, A .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (06) :F924-F928
[7]   PHOSPHORYLATION OF THE CATALYTIC SUBUNIT OF NA+,K+-ATPASE INHIBITS THE ACTIVITY OF THE ENZYME [J].
BERTORELLO, AM ;
APERIA, A ;
WALAAS, SI ;
NAIRN, AC ;
GREENGARD, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11359-11362
[8]   INHIBITORY EFFECT OF A MARINE-SPONGE TOXIN, OKADAIC ACID, ON PROTEIN PHOSPHATASES - SPECIFICITY AND KINETICS [J].
BIALOJAN, C ;
TAKAI, A .
BIOCHEMICAL JOURNAL, 1988, 256 (01) :283-290
[9]   RENAL NERVE ACTIVITY DOES NOT CONTRIBUTE TO THE DEVELOPMENT OF RENOVASCULAR HYPERTENSION IN RATS WITH ABDOMINAL AORTIC CONSTRICTION [J].
EKLOF, AC ;
HOKFELT, T ;
APERIA, A .
ACTA PHYSIOLOGICA SCANDINAVICA, 1991, 141 (01) :71-77
[10]  
Giebisch G, 1992, KIDNEY PHYSL PATHOPH, V2nd, P1157