DRUG RESIDUE FORMATION FROM RONIDAZOLE, A 5-NITROIMIDAZOLE .6. LACK OF MUTAGENIC ACTIVITY OF REDUCED METABOLITES AND DERIVATIVES OF RONIDAZOLE

被引:17
作者
WISLOCKI, PG [1 ]
BAGAN, ES [1 ]
COOK, MM [1 ]
BRADLEY, MO [1 ]
WOLF, FJ [1 ]
LU, AYH [1 ]
机构
[1] MERCK SHARP & DOHME RES LABS, DEPT SAFETY ASSESSMENT, West Point, PA 19486 USA
关键词
D O I
10.1016/0009-2797(84)90050-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:27 / 38
页数:12
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共 19 条
[11]   MUTAGENIC EFFECT OF 1,2-DICHLOROETHANE ON SALMONELLA-TYPHIMURIUM .1. ACTIVATION THROUGH CONJUGATION WITH GLUTATHION INVITRO [J].
RANNUG, U ;
SUNDVALL, A ;
RAMEL, C .
CHEMICO-BIOLOGICAL INTERACTIONS, 1978, 20 (01) :1-16
[12]   MUTAGENICITY OF METRONIDAZOLE - ACTIVATION BY MAMMALIAN LIVER-MICROSOMES [J].
ROSENKRANZ, HS ;
SPECK, WT .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 66 (02) :520-525
[13]   SYNTHESIS OF 1-(2-HYDROXYETHYL)-2-METHYL-5-AMINOIMIDAZOLE - A RING-INTACT REDUCTION PRODUCT OF METRONIDAZOLE [J].
SULLIVAN, CE ;
TALLY, FP ;
GOLDIN, BR ;
VOUROS, P .
BIOCHEMICAL PHARMACOLOGY, 1982, 31 (16) :2689-2691
[14]   MUTAGENIC ACTION OF NITROIMIDAZOLES .4. COMPARISON OF THE MUTAGENIC ACTION OF SEVERAL NITROIMIDAZOLES AND SOME IMIDAZOLES [J].
VOOGD, CE ;
VANDERSTEL, JJ ;
JACOBS, JJJAA .
MUTATION RESEARCH, 1979, 66 (03) :207-221
[15]  
WEBER NE, 1980, J ENVIRON PATHOL TOX, V3, P35
[16]   DRUG RESIDUE FORMATION FROM RONIDAZOLE, A 5-NITROIMIDAZOLE .1. CHARACTERIZATION OF INVITRO PROTEIN ALKYLATION [J].
WEST, SB ;
WISLOCKI, PG ;
FIORENTINI, KM ;
ALVARO, R ;
WOLF, FJ ;
LU, AYH .
CHEMICO-BIOLOGICAL INTERACTIONS, 1982, 41 (03) :265-279
[17]   DRUG RESIDUE FORMATION FROM RONIDAZOLE, A 5-NITROIMIDAZOLE .2. INVOLVEMENT OF MICROSOMAL NADPH-CYTOCHROME P-450 REDUCTASE IN PROTEIN ALKYLATION INVITRO [J].
WEST, SB ;
WISLOCKI, PG ;
WOLF, FJ ;
LU, AYH .
CHEMICO-BIOLOGICAL INTERACTIONS, 1982, 41 (03) :281-296
[18]   DRUG RESIDUE FORMATION FROM RONIDAZOLE, A 5-NITROIMIDAZOLE .5. CYSTEINE ADDUCTS FORMED UPON REDUCTION OF RONIDAZOLE BY DITHIONITE OR RAT-LIVER ENZYMES IN THE PRESENCE OF CYSTEINE [J].
WISLOCK, PG ;
BAGAN, ES ;
VANDENHEUVEL, WJA ;
WALKER, RW ;
ALVARO, RF ;
ARISON, BH ;
LU, AYH ;
WOLF, FJ .
CHEMICO-BIOLOGICAL INTERACTIONS, 1984, 49 (1-2) :13-25
[19]   DISPOSITION OF RONIDAZOLE BY SWINE .1. RADIOCARBON CONTENT OF TISSUES [J].
WOLF, FJ ;
BAYLIS, FP ;
SMITH, GE ;
ROSENBLUM, C ;
MERIWETHER, HT ;
ALVARO, RF ;
WOLF, DE ;
KONIUSZY, FR ;
JACOB, TA .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1983, 31 (03) :559-564