ENDOGENOUS ALKALOIDS IN MAN SYNTHESIS, ANALYTICS, INVIVO IDENTIFICATION, AND MEDICINAL IMPORTANCE

被引：10

作者：

BRINGMANN, G

FEINEIS, D

FRIEDRICH, H

HILLE, A

机构：

来源：

PLANTA MEDICA | 1991年 / 57卷

关键词：

NONENZYMATIC INVIVO CHEMISTRY; THERAPEUTIC TRAPPING OF HARMFUL METABOLITES; HOMOCYSTINURIA; HYPEROXALURIA; PICTET-SPENGLER REACTION; ISOQUINOLINES; BETA-CARBOLINES; THIAZOLIDINES; CHLORAL; PENICILLAMINE; VITAMIN-B6;

D O I：

10.1055/s-2006-960233

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The in vitro and in vivo condensation of endogenous (or administered) reactive amines and carbonyl compounds is reported, leading to alkaloid-type heterocycles. The spectrum of the presented "mammalian alkaloids" ranges from isoquinoline derivatives, via beta-carbolines, through to thiazolidines, arising from vitamin B6, chloral, and glyoxylic acid, respectively. Formation of these compounds may occur accidentally, but might also be induced intentionally, as a therapy for metabolic diseases.

引用

页码：S73 / S84

页数：12

共 41 条

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