DISTRIBUTION OF THE GABA-A RECEPTOR ALPHA-1-SUBUNIT AND GAMMA-2-SUBUNIT MESSENGER-RNAS IN CHICK BRAIN

被引：24

作者：

GLENCORSE, TA ^{[1
]}

BATESON, AN ^{[1
]}

HUNT, SP ^{[1
]}

DARLISON, MG ^{[1
]}

机构：

[1] MRC,MOLEC NEUROBIOL UNIT,CAMBRIDGE CB2 2QH,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1991年 / 133卷 / 01期

基金：

英国医学研究理事会;

关键词：

GAMMA-AMINOBUTYRIC ACIDA RECEPTOR; CHICK BRAIN; GENE EXPRESSION; INSITU HYBRIDIZATION; LIGAND-GATED ION CHANNEL; MESSENGER RNA LOCALIZATION; RECEPTOR SUBTYPE COMPOSITION;

D O I：

10.1016/0304-3940(91)90053-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have used sequence-specific oligonucleotide probes and in situ hybridisation histochemistry to examine the distributions of the GABA(A) receptor alpha-1- and gamma-2-subunit mRNAs in serial sections of 1-day-old chick brain. Both transcripts are present together, at high levels, in many brain regions. Differences are found, however, in the relative amounts of these mRNAs in two isthmic nuclei of the optic lobe, the deep cerebellar nuclei, and the dorsal thalamus. We therefore conclude that while the alpha-1 and gamma-2 subunits predominantly occur together in the same receptor complex, they may also be found separately in other GABA(A) receptor subtypes.

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页码：45 / 48

页数：4

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