A SENSITIVE CAPILLARY GC ASSAY FOR THE DETERMINATION OF SPARTEINE OXIDATION-PRODUCTS IN MICROSOMAL FRACTIONS OF HUMAN-LIVER

被引:31
作者
OSIKOWSKAEVERS, BA [1 ]
EICHELBAUM, M [1 ]
机构
[1] DR M FISCHER BOSCH INST CLIN PHARMACOL,STUTTGART,FED REP GER
关键词
D O I
10.1016/0024-3205(86)90128-1
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:1775 / 1782
页数:8
相关论文
共 24 条
[1]  
BOOBIS AR, 1983, MOL PHARMACOL, V23, P474
[2]   BIPHASIC O-DEETHYLATION OF PHENACETIN AND 7-ETHOXYCOUMARIN BY HUMAN AND RAT-LIVER MICROSOMAL FRACTIONS [J].
BOOBIS, AR ;
KAHN, GC ;
WHYTE, C ;
BRODIE, MJ ;
DAVIES, DS .
BIOCHEMICAL PHARMACOLOGY, 1981, 30 (17) :2451-2456
[3]  
BRAZEAU P, 1965, PHARM BASIS THERAPEU, P887
[4]  
DABBAGH SGA, 1981, J PHARM, V33, P161
[5]   EVIDENCE FOR AN ENZYMATIC DEFECT IN THE 4-HYDROXYLATION OF DEBRISOQUINE BY HUMAN-LIVER [J].
DAVIES, DS ;
KAHN, GC ;
MURRAY, S ;
BRODIE, MJ ;
BOOBIS, AR .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 11 (01) :89-91
[6]   CHARACTERIZATION OF A COMMON GENETIC-DEFECT OF CYTOCHROME-P-450 FUNCTION (DEBRISOQUINE-SPARTEINE TYPE POLYMORPHISM) - INCREASED MICHAELIS CONSTANT (KM) AND LOSS OF STEREOSELECTIVITY OF BUFURALOL 1'-HYDROXYLATION IN POOR METABOLIZERS [J].
DAYER, P ;
GASSER, R ;
GUT, J ;
KRONBACH, T ;
ROBERTZ, GM ;
EICHELBAUM, M ;
MEYER, UA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (01) :374-380
[7]  
DENGLER HJ, 1977, ARZNEIM FORSCH DRUG, V27, P1837
[8]  
DISTLERATH LM, 1985, J BIOL CHEM, V260, P9057
[9]   DEFECTIVE N-OXIDATION OF SPARTEINE IN MAN - NEW PHARMACOGENETIC DEFECT [J].
EICHELBAUM, M ;
SPANNBRUCKER, N ;
STEINCKE, B ;
DENGLER, HJ .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) :183-187
[10]  
EICHELBAUM M, 1978, BIOL OXIDATION NITRO, P113