CHRONIC MORPHINE-INDUCED HYPERACTIVITY IN RATS IS ALTERED BY NUCLEUS ACCUMBENS AND VENTRAL TEGMENTAL LESIONS

被引：29

作者：

BUNNEY, WC

MASSARI, VJ

PERT, A

机构：

[1] NIMH, BIOL PSYCHIAT BRANCH, BIOCHEM & PHARMACOL SECT, BETHESDA, MD 20205 USA

[2] HOWARD UNIV, DEPT PHARMACOL, WASHINGTON, DC 20059 USA

来源：

PSYCHOPHARMACOLOGY | 1984年 / 82卷 / 04期

关键词：

D O I：

10.1007/BF00427677

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lesions of the nucleus accumbens (NA) and the ventral tegmental area (VTA) attenuated and delayed the onset of the locomotor excitatory effects of morphine following chronic administration. Neither lesion totally prevented the increase in locomotor excitation. While the NA and VTA seem to play a role in mediating the excitatory effects of morphine, other regions and brain circuits may also be involved.

引用

页码：318 / 321

页数：4

共 18 条

[11] BIOCHEMICAL MAPPING OF THE NORADRENERGIC VENTRAL BUNDLE PROJECTION SITES - EVIDENCE FOR A NORADRENERGIC-DOPAMINERGIC INTERACTION
ODONOHUE, TL
CROWLEY, WR
JACOBOWITZ, DM
[J]. BRAIN RESEARCH, 1979, 172 (01) : 87 - 100
[12] NEUROANATOMICAL FOCUS FOR MORPHINE AND ENCEPHALIN-INDUCED HYPERMOTILITY
PERT, A
SIVIT, C
[J]. NATURE, 1977, 265 (5595) : 645 - 647
[13] PERT A, 1979, ENDORPHINS MENTAL HL, P145
[14] PERT CB, 1980, NEURAL PEPTIDES NEUR, P581
[15] IMMUNOHISTOCHEMICAL LOCALIZATION OF ENKEPHALIN IN RAT-BRAIN AND SPINAL-CORD
SAR, M
STUMPF, WE
MILLER, RJ
CHANG, KJ
CUATRECASAS, P
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 182 (01) : 17 - 37
[16] LOCOMOTOR ACTIVATION INDUCED BY INFUSION OF ENDORPHINS INTO THE VENTRAL TEGMENTAL AREA - EVIDENCE FOR OPIATE-DOPAMINE INTERACTIONS
STINUS, L
KOOB, GF
LING, N
BLOOM, FE
LEMOAL, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04): : 2323 - 2327
[17] DIFFERENTIAL EFFECTS OF LOCALIZED LESIONS OF N. ACCUMBENS ON MORPHINE-INDUCED AND AMPHETAMINE-INDUCED LOCOMOTOR HYPERACTIVITY IN THE C57BL-6J MOUSE
TEITELBAUM, H
GIAMMATTEO, P
MICKLEY, GA
[J]. JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1979, 93 (04) : 745 - 751
[18] NUCLEUS ACCUMBENS LESIONS REDUCE AMPHETAMINE HYPERTHERMIA BUT NOT HYPERACTIVITY
WIRTSHAFTER, D
ASIN, KE
KENT, EW
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 51 (04) : 449 - 452

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