ENZYME-LIKE RATE ACCELERATION IN THE DNA MINOR-GROOVE - CYCLOPROPYLPYRROLOINDOLES AS MECHANISM-BASED INACTIVATORS OF DNA

被引：46

作者：

WARPEHOSKI, MA

HARPER, DE

机构：

[1] Medicinal Chemistry, Upjohn Laboratories, Kalamazoo

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1995年 / 117卷 / 10期

关键词：

D O I：

10.1021/ja00115a040

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：2951 / 2952

页数：2

共 33 条

[1] LABILITY OF MONOFUNCTIONAL CISPLATINUM ADDUCTS - ROLE OF DNA DOUBLE HELIX [J].

ANIN, MF ;

GAUCHERON, F ;

LENG, M .

NUCLEIC ACIDS RESEARCH, 1992, 20 (18) :4825-4830

[2] THE REVERSIBLE DNA-ALKYLATING ACTIVITY OF DUOCARMYCIN AND ITS ANALOGS [J].

ASAI, A ;

NAGAMURA, S ;

SAITO, H ;

TAKAHASHI, I ;

NAKANO, H .

NUCLEIC ACIDS RESEARCH, 1994, 22 (01) :88-93

[3] A NOVEL PROPERTY OF DUOCARMYCIN AND ITS ANALOGS FOR COVALENT REACTION WITH DNA [J].

ASAI, A ;

NAGAMURA, S ;

SAITO, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (10) :4171-4177

[4] REVERSIBILITY OF THE DUOCARMYCIN-A AND SA DNA ALKYLATION REACTION [J].

BOGER, DL ;

YUN, WY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (21) :9872-9873

[5] SYNTHESIS AND PRELIMINARY EVALUATION OF AGENTS INCORPORATING THE PHARMACOPHORE OF THE DUOCARMYCIN PYRINDAMYCIN ALKYLATION SUBUNIT - IDENTIFICATION OF THE CC-1065 DUOCARMYCIN COMMON PHARMACOPHORE [J].

BOGER, DL ;

ISHIZAKI, T ;

ZARRINMAYEH, H ;

KITOS, PA ;

SUNTORNWAT, O .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (15) :4499-4502

[6] (+)- AND ENT-(-)-DUOCARMYCIN SA AND (+)- AND ENT-(-)-N-BOC-DSA DNA ALKYLATION PROPERTIES - ALKYLATION SITE MODELS THAT ACCOMMODATE THE OFFSET AT-RICH ADENINE N3 ALKYLATION SELECTIVITY OF THE ENANTIOMERIC AGENTS [J].

BOGER, DL ;

JOHNSON, DS ;

YUN, WY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (05) :1635-1656

[7] DUOCARMYCIN PYRINDAMYCIN DNA ALKYLATION PROPERTIES AND IDENTIFICATION, SYNTHESIS, AND EVALUATION OF AGENTS INCORPORATING THE PHARMACOPHORE OF THE DUOCARMYCIN PYRINDAMYCIN ALKYLATION SUBUNIT - IDENTIFICATION OF THE CC-1065-DUOCARMYCIN COMMON PHARMACOPHORE [J].

BOGER, DL ;

ISHIZAKI, T ;

ZARRINMAYEH, H ;

MUNK, SA ;

KITOS, PA ;

SUNTORNWAT, O .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (24) :8961-8971

[8] DNA ALKYLATION PROPERTIES OF ENHANCED FUNCTIONAL ANALOGS OF CC-1065 INCORPORATING THE 1,2,9,9A-TETRAHYDROCYCLOPROPA[1,2-C]BENZ[1,2-E]INDOL-4-ONE (CBI) ALKYLATION SUBUNIT [J].

BOGER, DL ;

MUNK, SA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (14) :5487-5496

[9] A REGIOSELECTIVE MECHANISM FOR MUTAGENESIS AND ONCOGENESIS CAUSED BY ALKYLNITROSOUREA SEQUENCE-SPECIFIC DNA ALKYLATION [J].

BUCKLEY, N .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (25) :7918-7920

[10] THE STRUCTURE OF CC-1065, A POTENT ANTI-TUMOR AGENT, AND ITS BINDING TO DNA [J].

CHIDESTER, CG ;

KRUEGER, WC ;

MIZSAK, SA ;

DUCHAMP, DJ ;

MARTIN, DG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (25) :7629-7635

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