ENT-16-ALPHA-METHYLAMINO-3-METHOXY-1,3,5(10)-ESTRATRIEN-17-BETA-OL HYDROCHLORIDE, A SELECTIVE ANTI-ARRHYTMIC ENANTIOSTEROID

被引：4

作者：

BOYD, A

GROEN, MB

HINDRIKSEN, B

MARSHALL, RJ

SLEIGH, T

WINSLOW, E

ZEELEN, FJ

机构：

来源：

STEROIDS | 1982年 / 40卷 / 06期

关键词：

D O I：

10.1016/0039-128X(82)90002-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The title compound and its antipode with natural steroid configuration were synthesized and tested. Both compounds showed equal potency as anti-arrhythmic compounds. An additional effect found for the steroid with natural configuration was its plasma cholesterol-lowering activity in the rat. Enantiosteroids may have a more selective action that the steroids with natural configuration.

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页码：615 / 623

页数：9

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