INVITRO GLUCOCORTICOSTEROID AND MINERALOCORTICOSTEROID BIOSYNTHESIS IN CONN ADENOMA TISSUES

被引：3

作者：

BOGDAN, A

AUZEBY, A

PLOUIN, PF

TOUITOU, Y

机构：

[1] FAC MED PITIE,DEPT BIOCHEM,91 BLVD HOP,F-75013 PARIS,FRANCE

[2] HOP BROUSSAIS,F-75674 PARIS 14,FRANCE

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1993年 / 16卷 / 01期

关键词：

HYPERALDOSTERONISM; CONN; INVITRO; BIOSYNTHESIS; CORTISOL; ALDOSTERONE; CORTICOSTERONE; 11-DEOXYCORTICOSTERONE; 18-HYDROXY-11-DEOXYCORTICOSTERONE; 18-HYDROXYCORTICOSTERONE;

D O I：

10.1007/BF03345834

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The in vitro metabolism of [1,2-H-3] deoxycorticosterone (DOC), [1,2-H-3] 18-hydroxy-11-deoxycorticosterone (18-OHDOC) and [1,2-H-3] 11-deoxycortisol (S) was studied in adrenal adenoma homogenates from patients with primary hyperaldosteronism. Tumor tissues actively converted deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone to 18-hydroxycorticosterone and aldosterone. Yields of cortisol and cortisone were also large showing that the tissues did not lack the zona fasciculata-like 11beta-hydroxylation ability.

引用

页码：65 / 68

页数：4

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