POSTIMMUNIZATION (VACCINATION) INJECTION-SITE REACTIONS - A REPORT OF 4 CASES AND REVIEW OF THE LITERATURE

被引:50
作者
MILIAUSKAS, JR [1 ]
MUKHERJEE, T [1 ]
DIXON, B [1 ]
机构
[1] INST MED & VET SCI,DIV TISSUE PATHOL,ELECTRON MICROSCOP UNIT,ADELAIDE,SA 5000,AUSTRALIA
关键词
GRANULOMA; ALUMINUM; INJECTION; VACCINATION; LYMPHOID HYPERPLASIA;
D O I
10.1097/00000478-199305000-00012
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Four patients each had a single subcutaneous nodule at the site of a previous vaccine injection; three after injection of diphtheria, tetanus, and per-tussis vaccination and one after tetanus toxoid vaccination. Presentation was with a mass 4-22 months after vaccination at the site of injection. Histologically, three patients had a necrotizing granulomatous reaction with a surrounding infiltrate of lymphocytes, plasma cells, histiocytes, and associated fibrosis. The fourth patient demonstrated a lymphohistiocytic reaction with a predominance of histiocytic cells as well as associated plasma cells, fibroblasts, and fibrosis. The lymphoid infiltration in these reactions showed a predominance of T-lymphocytes over B-lymphocytes. Aluminum was demonstrated in necrotic foci, inflammatory stroma, and the granular cytoplasm of histiocytes with the aid of solochrome azurine and solochrome cyanine stains as well as by energy-dispersive x-ray microanalysis. The reactions are thought to be immunologic (hypersensitivity) reactions associated with the aluminum contents of the preparation.
引用
收藏
页码:516 / 524
页数:9
相关论文
共 22 条
[1]   ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA ASSOCIATED WITH TETANUS TOXOID VACCINATION [J].
AKOSA, AB ;
ALI, MH ;
KHOO, CTK ;
EVANS, DM .
HISTOPATHOLOGY, 1990, 16 (06) :589-593
[2]  
BURLAND W. L., 1968, Medical Officer, V119, P17
[3]   ADVANTAGES OF ALUMINIUM HYDROXIDE ADSORBED COMBINED DIPHTHERIA TETANUS AND PERTUSSIS VACCINES FOR IMMUNIZATION OF INFANTS [J].
BUTLER, NR ;
BURLAND, WL ;
VOYCE, MA ;
HILTON, ML .
BMJ-BRITISH MEDICAL JOURNAL, 1969, 1 (5645) :663-+
[4]  
ENZINGER FM, 1988, SOFT TISSUE TUMORS, V2
[5]   ALUMINIUM HYDROXIDE GRANULOMA [J].
ERDOHAZI, M ;
NEWMAN, RL .
BRITISH MEDICAL JOURNAL, 1971, 3 (5775) :621-&
[6]   INJECTION-SITE GRANULOMA DUE TO ALUMINUM [J].
FAWCETT, HA ;
SMITH, NP .
ARCHIVES OF DERMATOLOGY, 1984, 120 (10) :1318-1322
[7]   PERSISTENT SUBCUTANEOUS NODULES IN CHILDREN HYPOSENSITIZED WITH ALUMINUM-CONTAINING ALLERGEN EXTRACTS [J].
FROST, L ;
JOHANSEN, P ;
PEDERSEN, S ;
VEIEN, N ;
OSTERGAARD, PA ;
NIELSEN, MH .
ALLERGY, 1985, 40 (05) :368-372
[8]   HISTOPATHOLOGICAL STUDIES OF REACTIONS IN MICE INJECTED WITH ALUMINUM-ADSORBED TETANUS TOXOID [J].
GOTO, N ;
AKAMA, K .
MICROBIOLOGY AND IMMUNOLOGY, 1982, 26 (12) :1121-1132
[9]   SUBCUTANEOUS NODULAR LYMPHOHISTIOCYTIC HYPERPLASIA [J].
HALE, JE ;
MACKENZIE, DH .
BRITISH JOURNAL OF SURGERY, 1972, 59 (05) :375-+
[10]  
HENDRICK MJ, 1991, J AM VET MED ASSOC, V198, P304