A CONVERGENT SYNTHESIS NOVEL CONFORMATIONALLY RESTRICTED HIV-1 PROTEASE INHIBITORS

被引：23

作者：

KIM, BM ^{[1
]}

GUARE, JP ^{[1
]}

HANIFIN, CM ^{[1
]}

ARFORDBICKERSTAFF, DJ ^{[1
]}

VACCA, JP ^{[1
]}

BALL, RG ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,DEPT BIOPHYS CHEM,RAHWAY,NJ 07065

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(00)77051-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conformationally restricted HIV-1 protease inhibitors containing the transition state hydroxyl group in pyrrolidine or piperidine ring systems were synthesized stereoselectively utilizing the inherent stereochemistry of an amino acid derivative. A convergent double reductive amination strategy was used to construct the heterocyclic rings.

引用

页码：5153 / 5156

页数：4

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