TOXINS FROM MAMBA VENOMS - SMALL PROTEINS WITH SELECTIVITIES FOR DIFFERENT SUBTYPES OF MUSCARINIC ACETYLCHOLINE-RECEPTORS

被引：77

作者：

JERUSALINSKY, D

HARVEY, AL

机构：

[1] UNIV STRATHCLYDE,DEPT PHYSIOL & PHARMACOL,GLASGOW G1 1XW,LANARK,SCOTLAND

[2] UNIV STRATHCLYDE,INST DRUG RES,GLASGOW G1 1XW,LANARK,SCOTLAND

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1994年 / 15卷 / 11期

关键词：

D O I：

10.1016/0165-6147(94)90092-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Muscarinic acetylcholine receptors exist as five subtypes that are widely distributed throughout the body. Conventional pharmacological agents are not highly selective for particular subtypes, making investigations on the functional significance of the subtypes difficult. Recent findings indicate that mamba snake Venoms contain several small proteins ('muscarinic toxins') that are highly specific for muscarinic receptors, and are discussed in this review by Diana Jerusalinsky and Alan Harvey. Some of these toxins act selectively and irreversibly on individual subtypes Of receptor, and some a re antagonists, while others activate muscarinic receptors. The toxins should be useful tools in studies of the functions of individual receptor subtypes, and comparisons of their three-dimensional structures should give clues about how selective binding to muscarinic receptor subtypes can be obtained.

引用

页码：424 / 430

页数：7

共 35 条

[21] JERUSALINSKY D, IN PRESS TOXICON
[22] JOLKKONEN M, IN PRESS TOXICON
[23] JOLKKONEN M, 1993, TOXICON, V31, P524
[24] AMINO-ACID-SEQUENCE OF A SNAKE-VENOM TOXIN THAT BINDS TO THE MUSCARINIC ACETYLCHOLINE-RECEPTOR
KARLSSON, E
RISINGER, C
JOLKKONEN, M
WERNSTEDT, C
ADEM, A
[J]. TOXICON, 1991, 29 (4-5) : 521 - 526
[25] PROTEIN TOXINS THAT BIND TO MUSCARINIC ACETYLCHOLINE-RECEPTORS
KARLSSON, E
JOLKKONEN, M
SATYAPAN, N
ADEM, A
KUMLIN, E
HELLMAN, U
WERNSTEDT, C
[J]. TOXINS AND EXOCYTOSIS, 1994, 710 : 153 - 161
[26] LEVEY AI, 1991, J NEUROSCI, V11, P3218
[27] MAX SI, 1993, J NEUROSCI, V13, P4293
[28] MAX SI, 1993, MOL PHARMACOL, V44, P1171
[29] MAX SI, 1993, J PHARMACOL EXP THER, V267, P480
[30] MAMBIN, A POTENT GLYCOPROTEIN-IIB-IIIA ANTAGONIST AND PLATELET-AGGREGATION INHIBITOR STRUCTURALLY RELATED TO THE SHORT NEUROTOXINS
MCDOWELL, RS
DENNIS, MS
LOUIE, A
SHUSTER, M
MULKERRIN, MG
LAZARUS, RA
[J]. BIOCHEMISTRY, 1992, 31 (20) : 4766 - 4772

← 1 2 3 4 →