ASYMMETRIC MICHAEL ADDITIONS OF GRIGNARD-REAGENTS TO CINNAMAMIDES DERIVING FROM N-ALKYL (R)-(-)-2-AMINOBUTAN-1-OL

被引：19

作者：

TOUET, J

BAUDOUIN, S

BROWN, E

机构：

[1] Laboratoire de Synth`ese Organique (URA 482), Faculté des Sciences, 72017 Le Mans, Avenue Olivier Messiaen

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(00)82287-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction of cinnamoyl chloride with various N-alkyl derivatives of (R)-(-)-2-aminobutan-1-ol (a readily available reagent) afforded the corresponding cinnamamides. Michael additions of Grignard reagents to the latter, followed by acidic hydrolysis, yielded optically active beta-phenylalkanoic acids whose ee most generally were in the range 72-100%.

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页码：587 / 590

页数：4

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