SYNTHESIS OF 2'-O-METHYL-6,3'-ETHANOURIDINE AND ITS INTRODUCTION INTO ANTISENSE OLIGONUCLEOTIDES

被引：15

作者：

BEVIERRE, MO

DEMESMAEKER, A

WOLF, RM

FREIER, SM

机构：

[1] CIBA GEIGY LTD,CENT RES LABS,CH-4002 BASEL,SWITZERLAND

[2] ISIS PHARMACEUT,CARLSBAD,CA 92008

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80121-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A molecular modelling study and a synthesis of title compound 1 are presented. This novel modified nucleoside was introduced into different oligonucleotides and the corresponding melting temperatures of the duplexes formed with the complementary RNA were measured.

引用

页码：237 / 240

页数：4

共 14 条

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