FACILE SYNTHESES OF GEM-DIFLUOROALKENES FROM CHLORODIFLUOROMETHYLKETONES

被引：9

作者：

BEGUE, JP

BONNETDELPON, D

PERCY, JM

ROCK, MH

WILKES, RD

机构：

[1] UNIV BIRMINGHAM,SCH CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[2] FAC PHARM CHATENAY MALABRY,BIOCIS,CNRS,F-92296 CHATENAY MALABRY,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 18期

关键词：

D O I：

10.1039/c39950001857

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chlorodifluoromethyl ketones reacted with diazomethane to afford epoxides in high yield; upon treatment with butyllithium, the epoxides underwent efficient ring opening to afford 3,3-difluoro-2-alkyl-alken-1-ols, suitable substrates for sigmatropic rearrangement leading to compounds containing a CF2 group in mid-chain.

引用

页码：1857 / 1857

页数：1

共 17 条

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