VASORELAXANT EFFECT OF MEXILETINE IN MESENTERIC RESISTANCE ARTERIES OF RATS

被引：13

作者：

DOHI, Y

KOJIMA, M

SATO, K

机构：

[1] Division of Hypertension and Vascular Research, Second Department of Internal Medicine, Nagoya City University Hospital, Nagoya, 467, Mizuho-ku

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1994年 / 111卷 / 03期

关键词：

5-HYDROXYTRYPTAMINE; RAT MESENTERIC ARTERY; MEXILETINE; NORADRENALINE; RELAXATION;

D O I：

10.1111/j.1476-5381.1994.tb14790.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The vascular action of mexiletine, a class Ib antiarrhythmic agent, was inve 2 The second order branch of the mesenteric artery was cut into rings and changes in isometric tension were recorded. 3 Mexiletine (10(-6)-10(-3) M) evoked concentration-dependent, endothelium-independent relaxations in arteries contracted with noradrenaline. 4 Mexiletine (10(-4) M) did not affect the contraction induced by noradrenaline in Ca2+-free solution, while the compound inhibited the contraction induced by CaCl2 in noradrenaline-activated arteries.

引用

页码：673 / 680

页数：8

共 36 条

[1] EFFECTS OF LOCAL-ANESTHETICS, ANTIHISTAMINES, AND GLUCOCORTICOIDS ON PERIPHERAL-BLOOD FLOW AND VASCULAR SMOOTH-MUSCLE [J].

ALTURA, BM ;

ALTURA, BT .

ANESTHESIOLOGY, 1974, 41 (02) :197-214

[2] SOME QUANTITATIVE USES OF DRUG ANTAGONISTS [J].

ARUNLAKSHANA, O ;

SCHILD, HO .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1959, 14 (01) :48-58

[3]

BELTRAME J, 1984, J CARDIOVASC PHARM, V6, P483

[4] REGULATION OF ARTERIAL TONE BY ACTIVATION OF CALCIUM-DEPENDENT POTASSIUM CHANNELS [J].

BRAYDEN, JE ;

NELSON, MT .

SCIENCE, 1992, 256 (5056) :532-535

[5] VASCULAR EFFECTS OF LIGNOCAINE AFTER CORONARY-ARTERY SURGERY [J].

CHIAVARELLI, M ;

CHIAVARELLI, R ;

FABI, F ;

STATI, T ;

DELBASSO, P .

LANCET, 1990, 335 (8697) :1101-1102

[6] IMPAIRED ENDOTHELIUM-DEPENDENT RELAXATIONS IN HYPERTENSIVE RESISTANCE ARTERIES INVOLVE CYCLOOXYGENASE PATHWAY [J].

DIEDERICH, D ;

YANG, ZH ;

BUHLER, FR ;

LUSCHER, TF .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (02) :H445-H451

[7] ACTIVATION OF ENDOTHELIAL L-ARGININE PATHWAY IN RESISTANCE ARTERIES - EFFECT OF AGE AND HYPERTENSION [J].

DOHI, Y ;

THIEL, MA ;

BUHLER, FR ;

LUSCHER, TF .

HYPERTENSION, 1990, 16 (02) :170-179

[8]

DOHI Y, 1990, J HYPERTENS, V8, P261

[9] CALCIUM RELEASE FROM SARCOPLASMIC-RETICULUM [J].

ENDO, M .

PHYSIOLOGICAL REVIEWS, 1977, 57 (01) :71-108

[10] HEMODYNAMIC-EFFECTS OF MEXILETINE AND LIDOCAINE IN CORONARY SURGERY PATIENTS [J].

FRITZ, KW ;

LULLWITZ, E ;

SCHELD, H ;

KIRCHNER, E .

ANASTHESIE INTENSIVTHERAPIE NOTFALLMEDIZIN, 1983, 18 (03) :125-128

← 1 2 3 4 →