VASORELAXANT EFFECT OF MEXILETINE IN MESENTERIC RESISTANCE ARTERIES OF RATS

被引：13

作者：

DOHI, Y

KOJIMA, M

SATO, K

机构：

[1] Division of Hypertension and Vascular Research, Second Department of Internal Medicine, Nagoya City University Hospital, Nagoya, 467, Mizuho-ku

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1994年 / 111卷 / 03期

关键词：

5-HYDROXYTRYPTAMINE; RAT MESENTERIC ARTERY; MEXILETINE; NORADRENALINE; RELAXATION;

D O I：

10.1111/j.1476-5381.1994.tb14790.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The vascular action of mexiletine, a class Ib antiarrhythmic agent, was inve 2 The second order branch of the mesenteric artery was cut into rings and changes in isometric tension were recorded. 3 Mexiletine (10(-6)-10(-3) M) evoked concentration-dependent, endothelium-independent relaxations in arteries contracted with noradrenaline. 4 Mexiletine (10(-4) M) did not affect the contraction induced by noradrenaline in Ca2+-free solution, while the compound inhibited the contraction induced by CaCl2 in noradrenaline-activated arteries.

引用

页码：673 / 680

页数：8

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