VASORELAXANT EFFECT OF MEXILETINE IN MESENTERIC RESISTANCE ARTERIES OF RATS

被引：13

作者：

DOHI, Y

KOJIMA, M

SATO, K

机构：

[1] Division of Hypertension and Vascular Research, Second Department of Internal Medicine, Nagoya City University Hospital, Nagoya, 467, Mizuho-ku

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1994年 / 111卷 / 03期

关键词：

5-HYDROXYTRYPTAMINE; RAT MESENTERIC ARTERY; MEXILETINE; NORADRENALINE; RELAXATION;

D O I：

10.1111/j.1476-5381.1994.tb14790.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The vascular action of mexiletine, a class Ib antiarrhythmic agent, was inve 2 The second order branch of the mesenteric artery was cut into rings and changes in isometric tension were recorded. 3 Mexiletine (10(-6)-10(-3) M) evoked concentration-dependent, endothelium-independent relaxations in arteries contracted with noradrenaline. 4 Mexiletine (10(-4) M) did not affect the contraction induced by noradrenaline in Ca2+-free solution, while the compound inhibited the contraction induced by CaCl2 in noradrenaline-activated arteries.

引用

页码：673 / 680

页数：8

共 36 条

[31] INHIBITION OF PROSTAGLANDIN SYNTHESIS AS A MECHANISM OF ACTION FOR ASPIRIN-LIKE DRUGS [J].

VANE, JR .

NATURE-NEW BIOLOGY, 1971, 231 (25) :232-&

[32] POPULATION PHARMACOKINETIC PARAMETERS IN PATIENTS TREATED WITH ORAL MEXILETINE [J].

VOZEH, S ;

KATZ, G ;

STEINER, V ;

FOLLATH, F .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 23 (05) :445-451

[33] EFFECTS OF LIDOCAINE AND PROCAINE ON CANINE NASAL BLOOD-VESSELS [J].

WANG, HW ;

JACKSON, RT .

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1988, 97 (04) :409-413

[34] A CLASSIFICATION OF ANTIARRHYTHMIC ACTIONS REASSESSED AFTER A DECADE OF NEW DRUGS [J].

WILLIAMS, EMV .

JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 24 (04) :129-147

[35] POSITIVE SURFACE-CHARGE INHIBITION OF PHOSPHOLIPASE-A-2 IN MIXED MONOLAYER SYSTEMS [J].

WILLMAN, C ;

HENDRICKSON, HS .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1978, 191 (01) :298-305

[36] PHARMACOLOGY, ELECTROPHYSIOLOGY, AND PHARMACOKINETICS OF MEXILETINE [J].

WOOSLEY, RL ;

WANG, T ;

STONE, W ;

SIDDOWAY, L ;

THOMPSON, K ;

DUFF, HJ ;

CERSKUS, I ;

RODEN, D .

AMERICAN HEART JOURNAL, 1984, 107 (05) :1058-1065

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