A NOVEL PROTEIN ENCODED BY THE INAD GENE REGULATES RECOVERY OF VISUAL TRANSDUCTION IN DROSOPHILA

被引：95

作者：

SHIEH, BH ^{[1
]}

NIEMEYER, B ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,LA JOLLA,CA 92093

来源：

NEURON | 1995年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0896-6273(95)90255-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

lnaD(p215) is a point mutation that affects photoreceptor function in Drosophila. To understand the molecular basis of the defect, we isolated the InaD gene and found it encodes a photoreceptor-specific polypeptide of 674 residues. Within its sequence are two repeats that share remarkable homology with a family of cytoskeleton-associated proteins that are involved in signal transduction. Patch-clamp recordings from isolated photoreceptor cells of InaD(p215) show a slow deactivation of the light-induced current. Th is defective deactivation of InaD appears dependent on calcium influx; removal of extracellular calcium masks its abnormal phenotype. Moreover, InaD photoreceptors show increased sensitivity to dim light. We propose that InaD is involved in the negative feedback regulation of the light-activated signaling cascade in Drosophila photoreceptors.

引用

页码：201 / 210

页数：10

共 50 条

[11]

FEIN A, 1986, TRENDS NEUROSCI, V93, P110

[12]

FERRIS CD, 1992, J NEUROSCI, V12, P1567

[13] SEVENLESS, A CELL-SPECIFIC HOMEOTIC GENE OF DROSOPHILA, ENCODES A PUTATIVE TRANSMEMBRANE RECEPTOR WITH A TYROSINE KINASE DOMAIN [J].