EFFECT OF PSYCHOTROPIC-DRUGS ON EXCITATORY AMINO-ACIDS IN PATIENTS UNDERGOING PSYCHOSURGERY FOR DEPRESSION

被引：18

作者：

PANGALOS, MN

MALIZIA, AL

FRANCIS, PT

LOWE, SL

BERTOLUCCI, PHF

PROCTER, AW

BRIDGES, PK

BARTLETT, JR

BOWEN, DM

机构：

[1] UNITED MED & DENT GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT PSYCHIAT,HOSP CAMPUS,LONDON SE1 9RJ,ENGLAND

[2] INST NEUROL,DEPT NEUROCHEM,LONDON WC1N 1PJ,ENGLAND

[3] BROOK GEN HOSP,GEOFFREY KNIGHT UNIT AFFECT DISORDERS,LONDON SE18 4LW,ENGLAND

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1992年 / 160卷

关键词：

D O I：

10.1192/bjp.160.5.638

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Samples of ventricular CSF were taken from 52 consecutive patients admitted for psychosurgery for intractable depression. Concentrations of asparagine, aspartate, glutamine, glutamic acid, and serine were determined. Glutamate and aspartate concentrations, implicated in excitotoxic brain damage, were not affected by various types of psychotropic drug treatment. Serine, a modulator of glutamate responses, was significantly elevated in samples from subjects receiving antidepressants. These subjects responded poorly to the operation. Psychotropic drugs are unlikely to be neurotoxic. Nevertheless, antidepressants may influence excitatory neutrotransmission.

引用

页码：638 / 642

页数：5

共 27 条

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