REGULATION OF MICROGLIAL FUNCTION BY INTERFERONS

被引：44

作者：

COLTON, CA ^{[1
]}

YAO, J ^{[1
]}

KERI, JE ^{[1
]}

GILBERT, D ^{[1
]}

机构：

[1] NINCDS,BIOPHYS LAB,BETHESDA,MD 20892

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 40卷 / 01期

关键词：

MICROGLIA; INTERFERON; SUPEROXIDE ANION; INTERLEUKIN-1;

D O I：

10.1016/0165-5728(92)90216-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cultured neonatal rat microglia were pretreated with varying doses of either purified interferon (IFN) alpha/beta or recombinant IFN-gamma for 24 or 48 h and the following functional parameters examined; superoxide anion production, interleukin-1 secretion and chemotaxis. IFN-gamma produced a marked increase in superoxide anion levels when PMA was used to initiate superoxide anion production but had no effect in OPZ-stimulated microglia. Treatment with IFN-alpha/beta potentiated superoxide anion production in both PMA and OPZ-stimulated cells. Interleukin-I activity was decreased by treatment with IFN-gamma for 24 h while IFN-alpha/beta increased IL-1 activity at 48 h. Removal of serum from the treatment media prevented the action of IFN-alpha/beta on IL-1 production. Treatment with IFN-alpha/beta or gamma decreased chemotaxis of microglia in response to zymosan activated serum. The data indicate that IFN-gamma and alpha/beta can regulate microglial function and that this regulation may differ from that seen for other monocytically derived macrophages.

引用

页码：89 / 98

页数：10

共 47 条

[1] MOLECULAR TRANSDUCTIONAL MECHANISMS BY WHICH IFN-GAMMA AND OTHER SIGNALS REGULATE MACROPHAGE DEVELOPMENT [J].