A LIPID-CONJUGATED IMMUNOSTIMULATING COMPLEX SUBUNIT VACCINE AGAINST SALMONELLA INFECTION IN TURKEYS

被引:17
作者
CHARLES, SD
NAGARAJA, KV
SIVANANDAN, V
机构
[1] Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, Paul
关键词
D O I
10.2307/1591675
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Immunostaining complexes (ISCOMs) are multimeric particles and have been used successfully for presentation of membrane proteins. In this study, outer-membrane proteins (OMPs) from Salmonella heidelberg were incorporated into lipid-conjugated ISCOM particles and evaluated for their use in a vaccine for turkeys against homologous and heterologous Salmonella challenge. Two types of lipid-conjugated ISCOMs were examined: ISCOM-phospholipid and ISCOM-sphingolipid preparations. The turkeys were challenged with one of the three Salmonella serotypes: S. heidelberg, S. reading, or S. enteritidis. The turkeys were monitored for clinical signs, shedding pattern post-challenge, and clearance of the challenge Salmonella from selected internal organs. Vaccines containing OMP with either lipid-conjugated ISCOM preparation produced significantly greater (P < 0.01) immune response than OMP alone. Cloacal swabs from turkeys given OMP along with ISCOM-phospholipid and challenged with a homologous serotype were completely negative for Salmonella. A certain degree of cross-protection against heterologous Salmonella was afforded by both OMP-ISCOM vaccines. The isolation rate of Salmonella from internal organs was significantly lower (P < 0.0001) in vaccinated turkeys than in unvaccinated controls.
引用
收藏
页码:477 / 484
页数:8
相关论文
共 46 条
  • [31] MOWAT AM, 1991, IMMUNOLOGY, V72, P317
  • [32] ISCOMS - A NOVEL STRATEGY FOR MUCOSAL IMMUNIZATION
    MOWAT, AM
    DONACHIE, AM
    [J]. IMMUNOLOGY TODAY, 1991, 12 (11): : 383 - 385
  • [33] Nagaraja K. V., 1991, Diseases of poultry., P99
  • [34] ROLE OF OUTER-MEMBRANE PROTEINS IN IMMUNITY AGAINST MURINE SALMONELLOSIS .1. ANTIBODY-RESPONSE TO CRUDE OUTER-MEMBRANE PROTEINS OF SALMONELLA-TYPHIMURIUM
    NATARAJAN, M
    UDHAYAKUMAR, V
    KRISHNARAJU, K
    MUTHUKKARUPPAN, V
    [J]. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 1985, 8 (01) : 9 - 16
  • [35] DEVELOPMENT OF A NEW TYPE OF INFLUENZA SUBUNIT VACCINE MADE BY MURAMYLDIPEPTIDE LIPOSOME - ENHANCEMENT OF HUMORAL AND CELLULAR IMMUNE-RESPONSES
    NEROME, K
    YOSHIOKA, Y
    ISHIDA, M
    OKUMA, K
    OKA, T
    KATAOKA, T
    INOUE, A
    OYA, A
    [J]. VACCINE, 1990, 8 (05) : 503 - 509
  • [36] SEROLOGICAL RESPONSES IN CATS VACCINATED WITH FELV ISCOM AND AN INACTIVATED FELV VACCINE
    OSTERHAUS, A
    WEIJER, K
    UYTDEHAAG, F
    KNELL, P
    JARRETT, O
    AKERBLOM, L
    MOREIN, B
    [J]. VACCINE, 1989, 7 (02) : 137 - 141
  • [37] SERUM ANTIBODY-RESPONSES TO THE OUTER-MEMBRANE PROTEINS OF BORDETELLA-PERTUSSIS
    REDHEAD, K
    [J]. INFECTION AND IMMUNITY, 1984, 44 (03) : 724 - 729
  • [38] STRUCTURE AND BIOLOGICAL PROPERTIES OF SOLUBILIZED ENVELOPE PROTEINS OF BORDETELLA-PERTUSSIS
    ROBINSON, A
    HAWKINS, DC
    [J]. INFECTION AND IMMUNITY, 1983, 39 (02) : 590 - 598
  • [39] EVALUATION OF THE HUMAN IMMUNE-RESPONSE TO OUTER-MEMBRANE PROTEINS OF VIBRIO-CHOLERAE
    SEARS, SD
    RICHARDSON, K
    YOUNG, C
    PARKER, CD
    LEVINE, MM
    [J]. INFECTION AND IMMUNITY, 1984, 44 (02) : 439 - 444
  • [40] SNOEYENBOS GH, 1991, DIS POULTRY, P72