SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-HETEROTRIBACTAMS

被引：13

作者：

DIFABIO, R

FERIANI, A

GAVIRAGHI, G

ROSSI, T

机构：

[1] Department of Medicinal Chemistry Glaxo Research Laboratories, 37138 Verona

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 12期

关键词：

D O I：

10.1016/0960-894X(95)00202-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and the preliminary microbiological activity of some tryciclic beta-lactam derivatives designed combining the structural features of the natural carbapenems and the synthetic ''tribnctams'' are described.

引用

页码：1235 / 1240

页数：6

共 29 条

[11]

GEORGOPAPADAKOU NH, 1988, ANTIMICROBIAL AGENTS, V3, P409

[12] SYNTHESIS AND BIOLOGICAL EVALUATION OF 1-SUBSTITUTED-7-(1-HYDROXYETHYL) CARBACEPHEMS - A CLASS OF HYBRID BICYCLIC BETA-LACTAMS [J].

HANESSIAN, S ;

ROZEMA, MJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (19) :2279-2284

[13] A NOVEL RING-CLOSURE STRATEGY FOR THE CARBAPENEMS - THE TOTAL SYNTHESIS OF (+)-THIENAMYCIN [J].

HANESSIAN, S ;

DESILETS, D ;

BENNANI, YL .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (10) :3098-3103

[14] HOMOGENEOUS, PALLADIUM(0)-CATALYZED EXCHANGE DEPROTECTION OF ALLYLIC ESTERS, CARBONATES, AND CARBAMATES [J].

JEFFREY, PD ;

MCCOMBIE, SW .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (03) :587-590

[15]

KAHAN JS, 1979, J ANTIBIOT, V32, P1

[16] SYNTHESIS OF CARBAPENEM ANTIBIOTICS [J].

KAMETANI, T ;

FUKUMOTO, K ;

IHARA, M .

HETEROCYCLES, 1982, 17 :463-506

[17]

LEANZA WJ, 1979, J MED CHEM, V22, P1435, DOI 10.1021/jm00198a001

[18]

NAGAHARA T, 1987, HETEROCYCLES, V25, P729

[19]

Neuhaus F. C., 1992, EMERGING TARGETS ANT

[20]

PFLANDER HR, 1981, J AM CHEM SOC, V103, P4526

← 1 2 3 →