STRUCTURE-ACTIVITY-RELATIONSHIPS OF SOME 4-QUINAZOLYLTHIOSEMICARBAZIDES AND THEIR TRIAZOLO DERIVATIVES

被引：6

作者：

JANTOVA, S ^{[1
]}

HUDECOVA, D ^{[1
]}

SPIRKOVA, K ^{[1
]}

STANKOVSKY, S ^{[1
]}

机构：

[1] SLOVAK UNIV TECHNOL BRATISLAVA, FAC CHEM TECHNOL, DEPT ORGAN CHEM, BRATISLAVA 81237, SLOVAKIA

来源：

FOLIA MICROBIOLOGICA | 1994年 / 39卷 / 06期

关键词：

D O I：

10.1007/BF02814064

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Eight 4-quinazolylthiosemicarbazides and nine of their structural analogues have been tested for antibacterial effects and for structure activity relationships. 9-Chloro-5-morpholino-1,2,4-triazolo[4,3-c]quinazoline-3-thione has demonstrated the hightest antibacterial effect (MIC of 1 mg/L for E, coli and P. mirabilis; and <1 mg/L for S. aureus and B. subtilis). The most effective derivatives have the carbon aromatic ring substituted with chlorine and the pyrimidine ring with morpholine or with secondary amine group.

引用

页码：471 / 474

页数：4

共 17 条

[1] ANTIMICROBIAL PROPERTIES OF FUNGAL MACROLIDE ANTIBIOTICS [J].

BETINA, V ;

MICEKOVA, D .

ZEITSCHRIFT FUR ALLGEMEINE MIKROBIOLOGIE, 1972, 12 (05) :355-&

[2]

CHAURASIA MR, 1980, HETEROCYCLES, V14, P1759

[3] STUDIES ON QUINAZOLINONES .3. NOVEL AND EFFICIENT ROUTE TO THE SYNTHESIS OF CONFORMATIONALLY RESTRICTED ANALOGS OF KETANSERIN AND SGB-1534 AS ANTIHYPERTENSIVE AGENTS [J].

CHERN, JW ;

SHIAU, CY ;

LU, GY .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (11) :571-&

[4]

ELZOHRY MF, 1992, J CHEM TECHNOL BIOT, V53, P329, DOI 10.1002/jctb.280530403

[5] NONSTEROIDAL ANTIINFLAMMATORY AGENTS - SYNTHESIS OF NOVEL 2-PYRAZOLYL-4(3H)-QUINAZOLINONES [J].

FARGHALY, AM ;

CHAABAN, I ;

KHALIL, MA ;

BEKHIT, AA .

ARCHIV DER PHARMAZIE, 1990, 323 (10) :833-836

[6]

GABRIEL S, 1903, BER DEUT CHEM GES, V36, P800

[7] HETEROCYCLIC QUINONES .17. A NEW INVIVO ACTIVE ANTINEOPLASTIC DRUG - 6,7-BIS(1-AZIRIDINYL)-4-[[3-(N,N-DIMETHYLAMINO)PROPYL]AMINO]-5,8-QUINAZOLINEDIONE [J].

GIORGIRENAULT, S ;

RENAULT, J ;

GEBELSERVOLLES, P ;

BARON, M ;

PAOLETTI, C ;

CROS, S ;

BISSERY, MC ;

LAVELLE, F ;

ATASSI, G .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) :38-46

[8]

Griess P., 1869, BER DEUT CHEM GES, V2, P415

[9] SYNTHESIS AND ANTICONVULSANT ACTIVITY OF 3-ALKYL-3,4-DIHYDRO-2(1H)-QUINAZOLINONES [J].

KORNET, MJ .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1992, 29 (01) :103-105

[10]

NAITHANI PK, 1989, INDIAN J CHEM B, V28, P745

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