ANERGIC T-CELLS AS SUPPRESSOR CELLS IN-VITRO

被引：348

作者：

LOMBARDI, G ^{[1
]}

SIDHU, S ^{[1
]}

BATCHELOR, R ^{[1
]}

LECHLER, R ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH,DEPT IMMUNOL,LONDON W12 0NN,ENGLAND

来源：

SCIENCE | 1994年 / 264卷 / 5165期

关键词：

D O I：

10.1126/science.8202711

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

T cell-mediated suppression is an established phenomenon, but its underlying mechanisms are obscure. An in vitro system was used to test the possibility that anergic T cells can act as specific suppressor cells. Anergic human T cells caused inhibition of antigen-specific and allospecific T cell proliferation. In order for the inhibition to occur, the anergic T cells had to be specific for the same antigen-presenting cells (APCs) as the T cells that were suppressed. The mechanism of this suppression appears to be competition for the APC surface and for locally produced interleukin-2.

引用

页码：1587 / 1589

页数：3

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