PREPARATION OF 2-ARYL-SUBSTITUTED AND 2-ALKENYL-SUBSTITUTED CARBAPENEMS UNDER MILD SUZUKI CROSS-COUPLING CONDITIONS

被引：37

作者：

YASUDA, N

XAVIER, L

RIEGER, DL

LI, YL

DECAMP, AE

DOLLING, UH

机构：

[1] Department of Process Research, Merck Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)73663-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An extraordinarily mild procedure for the synthesis of 2-aryl- and 2-alkenyl-substituted carbapenems via palladium-catalyzed coupling of a vinyl triflate with aryl or vinyl boronic acids is described. A major advantage of this procedure is the use of nontoxic boronic acid intermediates in place of highly toxic organostannane compounds which are used in the corresponding Stille cross-coupling reactions.

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页码：3211 / 3214

页数：4

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