DETERMINATION AND QUANTITATIVE-ANALYSIS OF ACONITUM ALKALOIDS IN PLANTS BY LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRY

被引：20

作者：

WADA, K

BANDO, H

KAWAHARA, N

机构：

[1] Hokkaido Institute of Pharmaceutical Sciences, Otaru, 047-02, 7-1, Katsuraoka-cho

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 644卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)80118-R

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry method was useful for the simultaneous determination of Aconitum alkaloids, kobusine, pseudokobusine, dehydrolucidusculine. lucidusculine, delcosine and 14-acetyldelcosine, found in the Aconitum yesoense var. macroyesoense. These compounds were chromatographed by definite elution in 10 min and were quantitated by selected-ion monitoring of the protonated molecules. The method is linear over the range 10 ng to 10 mug of alkaloids per injection. The detection limits of alkaloids were ca. 1-5 ng per injection.

引用

收藏

页码：43 / 48

页数：6

相关论文

共 18 条

[1]

Amiya T., 1988, ALKALOIDS, P95

[2] ANALYSIS OF TROPANE ALKALOIDS WITH THERMOSPRAY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY [J].

AURIOLA, S ;

MARTINSEN, A ;

OKSMANCALDENTEY, KM ;

NAARANLAHTI, T .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1991, 562 (1-2) :737-744

[3] THERMOSPRAY LIQUID-CHROMATOGRAPHIC MASS-SPECTROMETRIC ANALYSIS OF CATHARANTHUS ALKALOIDS [J].

AURIOLA, S ;

RANTA, VP ;

NAARANLAHTI, T ;

LAPINJOKI, SP .

JOURNAL OF CHROMATOGRAPHY, 1989, 474 (01) :181-185

[4] DETERMINATION OF CATHARANTHUS ALKALOIDS IN PLANT-CELL CULTURES BY THERMOSPRAY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY [J].

AURIOLA, S ;

NAARANLAHTI, T ;

KOSTIAINEN, R ;

LAPINJOKI, SP .

BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1990, 19 (10) :609-612

[5] DETERMINATION OF CATHARANTHUS-ROSEUS ALKALOIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ISOTOPE-DILUTION THERMOSPRAY-MASS SPECTROMETRY [J].

AURIOLA, S ;

NAARANLATI, T ;

LAPINJOKI, SP .

JOURNAL OF CHROMATOGRAPHY, 1991, 554 (1-2) :227-231

[6]

BANDO H, 1985, CHEM PHARM BULL, V33, P4717

[7]

BANDO H, 1987, HETEROCYCLES, V26, P2623

[8] SEPARATION AND QUANTITATION OF NICERGOLINE AND RELATED SUBSTANCES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE IONIZATION MASS-SPECTROMETRY [J].

BANNO, K ;

HORIMOTO, S .

CHROMATOGRAPHIA, 1991, 31 (1-2) :50-54

[9] ASSAY OF NICERGOLINE AND 3 METABOLITES IN HUMAN PLASMA AND URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE IONIZATION MASS-SPECTROMETRY [J].

BANNO, K ;

HORIMOTO, S ;

MABUCHI, M .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1991, 568 (02) :375-384

[10] DRUG ANALYSIS BY CONTINUOUSLY MONITORED LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY WITH A QUADRUPOLE MASS-SPECTROMETER [J].

HENION, JD .

ANALYTICAL CHEMISTRY, 1978, 50 (12) :1687-1693