AN INVESTIGATION OF JAPANESE SUBJECTS MAPS SUSCEPTIBILITY TO TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS CLOSE TO THE DQA1 GENE

被引：19

作者：

JACOBS, KH ^{[1
]}

JENKINS, D ^{[1
]}

MIJOVIC, C ^{[1
]}

PENNY, M ^{[1
]}

UCHIGATA, Y ^{[1
]}

CAVAN, D ^{[1
]}

HIRATA, Y ^{[1
]}

OTANI, T ^{[1
]}

FLETCHER, J ^{[1
]}

BARNETT, AH ^{[1
]}

机构：

[1] TOKYO WOMENS MED COLL,CTR DIABET,TOKYO 162,JAPAN

来源：

HUMAN IMMUNOLOGY | 1992年 / 33卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0198-8859(92)90048-R

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Insulin-dependent diabetic and control subjects of Japanese origin were HLA-DRB1, -DQB1, and -DQA1 typed using restriction fragment length polymorphism analysis and sequence-specific oligonucleotide gene probing. The DQA1 allele DQA1*0301 was positively associated with the disease [48/52 (92%) diabetic patients versus 44/64 (69%) control subjects, P(c) < 0.03, RR = 4.97]. Alleles of the DRB1 and DQB1 genes showed no significant assoication with the disease. The frequency of DQB1 genotypes encoding the amino acid aspartic acid at position 57 of the DQ-beta chain did not differ significantly between subjects with insulin-dependent diabetes mellitus (IDDM) and controls. These findings suggest that a susceptibility allele for IDDM in the Japanese is more closely associated with the DQA1 gene than the DQB1 gene.

引用

页码：24 / 28

页数：5

共 21 条

[1] HLA-DQ SYSTEM AND INSULIN-DEPENDENT DIABETES-MELLITUS IN JAPANESE - DOES IT CONTRIBUTE TO THE DEVELOPMENT OF IDDM AS IT DOES IN CAUCASIANS [J].