SYNTHESIS OF PSEUDO-DISACCHARIDES RELATED TO ALLOSAMIDIN

被引:18
作者
CORBETT, DF [1 ]
DEAN, DK [1 ]
ROBINSON, SR [1 ]
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,EPSOM KT18 5XQ,SURREY,ENGLAND
关键词
PSEUDO-DISACCHARIDES; ALLOSAMIDIN; GLUCOALLOSAMIDIN; CHITINASE INHIBITOR; STEREOSPECIFIC BETA-1,4-GLYCOSIDATION;
D O I
10.1016/0040-4039(94)85080-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Suitably protected carbocyclic pseudo-sugars were synthesised from D-glucosamine via a Ferrier rearrangement. Stereospecific coupling with the glycosyl donor, 1,3,4,6-retra-O-acetyl-2-deoxy-2-phthalimido-beta-D-glucopyranoside and subsequent protecting group interconversions furnished beta-1,4- pseudo-disaccharides related to the chitinase inhibitor, allosamidin.
引用
收藏
页码:459 / 462
页数:4
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