NUCLEAR SIGNALING BY INTERLEUKIN-6

被引：43

作者：

CHENKIANG, S

HSU, W

NATKUNAM, Y

ZHANG, XK

机构：

[1] Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 01期

关键词：

D O I：

10.1016/0952-7915(93)90091-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The molecular analysis of the regulation of nuclear proteins induced by interleukin-6 has provided new insights into this largely unknown signal transduction pathway. Transcription factors of the CCAAT/enhancer-binding protein and AP-1 families, as well as the octamer-binding proteins and the tumor suppressor gene product pRB, are regulated by interleukin-6 in a cell type specific manner, suggesting that they may play a role in the nuclear signaling by interleukin-6.

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页码：124 / 128

页数：5

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