USE OF BIOREVERSIBLE PHOSPHATE PROTECTING GROUPS FOR THE INTRACELLULAR DELIVERY OF ANTISENSE OLIGODEOXYRIBONUCLEOTIDES

被引：4

作者：

BARBER, I ^{[1
]}

RAYNER, B ^{[1
]}

IMBACH, JL ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,CNRS,URA 488,F-34095 MONTPELLIER 5,FRANCE

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012539

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this work was to design phosphorothioate oligonucleotides, the negative charges of which are temporarily masked by a group which facilitates the cellular uptake of these analogues. Then, selective removal of this group by enzymes normally present in the cells will deliver intracellularly the intact charged phosphorothioate oligomers able to hybridize to their complementary RNA targets and to elicit RNase H activity.

引用

页码：1083 / 1085

页数：3

共 4 条

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[4] PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES - ANTISENSE INHIBITORS OF GENE-EXPRESSION [J].

STEIN, CA ;

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