HEPATOCELLULAR-CARCINOMA IN JAPAN AND ITS LINKAGE TO INFECTION WITH HEPATITIS-C VIRUS

被引：26

作者：

SHIMOTOHNO, K

机构：

[1] Virology Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104

来源：

SEMINARS IN VIROLOGY | 1993年 / 4卷 / 05期

关键词：

HEPATITIS-C VIRUS; HEPATOCELLULAR CARCINOMA; GENETIC DIVERSITY; HEPATITIS; HYPER-VARIABILITY; PERSISTENT INFECTION;

D O I：

10.1006/smvy.1993.1027

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis B and C viruses are closely related to the development of liver cirrhosis and hepatocellular carcinoma. Recently these two viral agents were found to be the major causative agents of hepatocellular carcinoma in Japan. An increase in the number of HCV antibody-positive patients, but a decrease in the number of HBs antigen-positive patients with hepato cellular carcinoma has been noted over the last 15 years. In the late 1980s about 70% of the patients with hepatocellular carcinoma were found to be positive for HCV antibody and 24% for HBs antigen. Presence of several subtypes of HCV was reported. Hypervariable region (HVR) in a putative envelope, gp70, was detected within the same subtype. Variability of HVR seemed to be the result of spontaneous mutation caused after infection. Such changes with time in the sequence of the HCV genome in the blood of patients with type C hepatitis are likely to be due to immunological surveillance by the host. © 1993 Academic Press. All rights reserved.

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页码：305 / 312

页数：8

相关论文

共 26 条

[11] MARKED SEQUENCE DIVERSITY IN THE PUTATIVE ENVELOPE PROTEINS OF HEPATITIS-C VIRUSES [J].

KATO, N ;

OOTSUYAMA, Y ;

TANAKA, T ;

NAKAGAWA, M ;

NAKAZAWA, T ;

MURAISO, K ;

OHKOSHI, S ;

HIJIKATA, M ;

SHIMOTOHNO, K .

VIRUS RESEARCH, 1992, 22 (02) :107-123

[12] DISTRIBUTION OF PLURAL HCV TYPES IN JAPAN [J].

KATO, N ;

OOTSUYAMA, Y ;

OHKOSHI, S ;

NAKAZAWA, T ;

MORI, S ;

HIJIKATA, M ;

SHIMOTOHNO, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (01) :279-285

[13] JAPANESE ISOLATES OF THE NON-A, NON-B HEPATITIS VIRAL GENOME SHOW SEQUENCE VARIATIONS FROM THE ORIGINAL ISOLATE IN THE USA [J].

KATO, N ;

OHKOSHI, S ;

SHIMOTOHNO, K .

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1989, 65 (09) :219-223

[14] MOLECULAR-CLONING OF THE HUMAN HEPATITIS-C VIRUS GENOME FROM JAPANESE PATIENTS WITH NON-A, NON-B HEPATITIS [J].

KATO, N ;

HIJIKATA, M ;

OOTSUYAMA, Y ;

NAKAGAWA, M ;

OHKOSHI, S ;

SUGIMURA, T ;

SHIMOTOHNO, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) :9524-9528

[15] AN ASSAY FOR CIRCULATING ANTIBODIES TO A MAJOR ETIOLOGIC VIRUS OF HUMAN NON-A, NON-B-HEPATITIS [J].

KUO, G ;

CHOO, QL ;

ALTER, HJ ;

GITNICK, GL ;

REDEKER, AG ;

PURCELL, RH ;

MIYAMURA, T ;

DIENSTAG, JL ;

ALTER, MJ ;

STEVENS, CE ;

TEGTMEIER, GE ;

BONINO, F ;

COLOMBO, M ;

LEE, WS ;

KUO, C ;

BERGER, K ;

SHUSTER, JR ;

OVERBY, LR ;

BRADLEY, DW ;

HOUGHTON, M .

SCIENCE, 1989, 244 (4902) :362-364

[16] A NEW TYPE OF HEPATITIS-C VIRUS IN PATIENTS IN THAILAND [J].

MORI, S ;

KATO, N ;

YAGYU, A ;

TANAKA, T ;

IKEDA, Y ;

PETCHCLAI, B ;

CHIEWSILP, P ;

KURIMURA, T ;

SHIMOTOHNO, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 183 (01) :334-342

[17] NUCLEOTIDE-SEQUENCE AND MUTATION-RATE OF THE H-STRAIN OF HEPATITIS-C VIRUS [J].

OGATA, N ;

ALTER, HJ ;

MILLER, RH ;

PURCELL, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) :3392-3396

[18] PREVALENCE OF ANTIBODY TO HEPATITIS-C VIRUS IN A BLOOD-DONOR POPULATION [J].

RICHARDS, C ;

HOLLAND, P ;

KURAMOTO, K ;

DOUVILLE, C ;

RANDELL, R .

TRANSFUSION, 1991, 31 (02) :109-113

[19] STRUCTURE AND ORGANIZATION OF THE HEPATITIS-C VIRUS GENOME ISOLATED FROM HUMAN CARRIERS [J].

TAKAMIZAWA, A ;

MORI, C ;

FUKE, I ;

MANABE, S ;

MURAKAMI, S ;

FUJITA, J ;

ONISHI, E ;

ANDOH, T ;

YOSHIDA, I ;

OKAYAMA, H .

JOURNAL OF VIROLOGY, 1991, 65 (03) :1105-1113

[20]

TANAKA T, 1992, VIRUS RES, V23, P39