TOTAL SYNTHESIS OF (-)-QUINOCARCIN AND (-)-10-DECARBOXYQUINOCARCIN

被引：23

作者：

KATOH, T ^{[1
]}

KIRIHARA, M ^{[1
]}

NAGATA, Y ^{[1
]}

KOBAYASHI, Y ^{[1
]}

ARAI, K ^{[1
]}

MINAMI, J ^{[1
]}

TERASHIMA, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 36期

关键词：

TOTAL SYNTHESIS; QUINOCARCIN; 10-DECARBOXYQUINOCARCIN; ANTITUMOR ANTIBIOTIC; ALDOL COUPLING; DIASTEREOSELECTIVE REDUCTION; INTERMOLECULAR AMINAL FORMATION;

D O I：

10.1016/S0040-4039(00)73850-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title total synthesis was accomplished by employing diastereoselective reduction of 1, 3-disubstituted isoquinolines as a key step. The cytotoxicity of 10-decarboxyquinocarcin and its 7-cyano congeners were found to be 10-1000 times more potent than those of quinocarcin and its 7-cyano congeners against P388 murine leukemia.

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页码：5747 / 5750

页数：4

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